Adrenal Corticoid Activities of 2-Methylhydrocortisone Acetate and 2-Methyl-9a-Fluorohydrocortisone Acetate
Summary (1) Two new analogues of hydrocortisone, 2-methylhydrocortisone acetate and 2-methyl-9 α-fluorohydrocortisone acetate, have been tested for corticoid activity on the following assays: anti-inflammatory, glycogen deposition, muscle work, and sodium retention. A summary of the data is presente...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1956-01, Vol.91 (1), p.67-70 |
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| container_end_page | 70 |
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| container_issue | 1 |
| container_start_page | 67 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 91 |
| creator | Byrnes, William W. Barnes, Lester E. Bowman, Barbara J. Dulin, William E. Morley, Erving H. Stafford, Robert O. |
| description | Summary
(1) Two new analogues of hydrocortisone, 2-methylhydrocortisone acetate and 2-methyl-9 α-fluorohydrocortisone acetate, have been tested for corticoid activity on the following assays: anti-inflammatory, glycogen deposition, muscle work, and sodium retention. A summary of the data is presented in Table VI. (2) The sodium-retaining activity of 2-methyl-9 α-fluorohydrocortisone acetate is 90 x desoxycorticosterone acetate and is, therefore, one of the most potent mineralocorticoids. |
| doi_str_mv | 10.3181/00379727-91-22171 |
| format | Article |
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(1) Two new analogues of hydrocortisone, 2-methylhydrocortisone acetate and 2-methyl-9 α-fluorohydrocortisone acetate, have been tested for corticoid activity on the following assays: anti-inflammatory, glycogen deposition, muscle work, and sodium retention. A summary of the data is presented in Table VI. (2) The sodium-retaining activity of 2-methyl-9 α-fluorohydrocortisone acetate is 90 x desoxycorticosterone acetate and is, therefore, one of the most potent mineralocorticoids.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-91-22171</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>Experimental biology and medicine (Maywood, N.J.), 1956-01, Vol.91 (1), p.67-70</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c199t-40a0429a55655ef0d5b14a621879ddbc688bac96f65bc3cc1f664421ddb5c1f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Byrnes, William W.</creatorcontrib><creatorcontrib>Barnes, Lester E.</creatorcontrib><creatorcontrib>Bowman, Barbara J.</creatorcontrib><creatorcontrib>Dulin, William E.</creatorcontrib><creatorcontrib>Morley, Erving H.</creatorcontrib><creatorcontrib>Stafford, Robert O.</creatorcontrib><title>Adrenal Corticoid Activities of 2-Methylhydrocortisone Acetate and 2-Methyl-9a-Fluorohydrocortisone Acetate</title><title>Experimental biology and medicine (Maywood, N.J.)</title><description>Summary
(1) Two new analogues of hydrocortisone, 2-methylhydrocortisone acetate and 2-methyl-9 α-fluorohydrocortisone acetate, have been tested for corticoid activity on the following assays: anti-inflammatory, glycogen deposition, muscle work, and sodium retention. A summary of the data is presented in Table VI. (2) The sodium-retaining activity of 2-methyl-9 α-fluorohydrocortisone acetate is 90 x desoxycorticosterone acetate and is, therefore, one of the most potent mineralocorticoids.</description><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1956</creationdate><recordtype>article</recordtype><recordid>eNp9kLFOwzAURS0EEqXwAWz5ARc_J3biMYooVCpi6W45tkNdQoxsFyl_T0KBCTE9Xd1z33AQugWyyqGCO0LyUpS0xAIwpVDCGVoAyxnOuRDnaDH3eAYu0VWMB0KAlZQv0Gttgh1UnzU-JKe9M1mtk_twydmY-S6j-Mmm_djvRxO8nqHoBztBNqlkMzWYXwQLhdf90Qf_N3yNLjrVR3vzfZdot77fNY94-_ywaeot1iBEwgVRpKBCMcYZsx0xrIVCcQpVKYxpNa-qVmnBO85anWsNHedFQWHq2BTyJYLTWx18jMF28j24NxVGCUTOsuSPLClAfsmaNqvTJqoXKw_-GCYn8Z_BJ4L3a_w</recordid><startdate>195601</startdate><enddate>195601</enddate><creator>Byrnes, William W.</creator><creator>Barnes, Lester E.</creator><creator>Bowman, Barbara J.</creator><creator>Dulin, William E.</creator><creator>Morley, Erving H.</creator><creator>Stafford, Robert O.</creator><general>SAGE Publications</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>195601</creationdate><title>Adrenal Corticoid Activities of 2-Methylhydrocortisone Acetate and 2-Methyl-9a-Fluorohydrocortisone Acetate</title><author>Byrnes, William W. ; Barnes, Lester E. ; Bowman, Barbara J. ; Dulin, William E. ; Morley, Erving H. ; Stafford, Robert O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c199t-40a0429a55655ef0d5b14a621879ddbc688bac96f65bc3cc1f664421ddb5c1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1956</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Byrnes, William W.</creatorcontrib><creatorcontrib>Barnes, Lester E.</creatorcontrib><creatorcontrib>Bowman, Barbara J.</creatorcontrib><creatorcontrib>Dulin, William E.</creatorcontrib><creatorcontrib>Morley, Erving H.</creatorcontrib><creatorcontrib>Stafford, Robert O.</creatorcontrib><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Byrnes, William W.</au><au>Barnes, Lester E.</au><au>Bowman, Barbara J.</au><au>Dulin, William E.</au><au>Morley, Erving H.</au><au>Stafford, Robert O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenal Corticoid Activities of 2-Methylhydrocortisone Acetate and 2-Methyl-9a-Fluorohydrocortisone Acetate</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><date>1956-01</date><risdate>1956</risdate><volume>91</volume><issue>1</issue><spage>67</spage><epage>70</epage><pages>67-70</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
(1) Two new analogues of hydrocortisone, 2-methylhydrocortisone acetate and 2-methyl-9 α-fluorohydrocortisone acetate, have been tested for corticoid activity on the following assays: anti-inflammatory, glycogen deposition, muscle work, and sodium retention. A summary of the data is presented in Table VI. (2) The sodium-retaining activity of 2-methyl-9 α-fluorohydrocortisone acetate is 90 x desoxycorticosterone acetate and is, therefore, one of the most potent mineralocorticoids.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.3181/00379727-91-22171</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1956-01, Vol.91 (1), p.67-70 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_sage_journals_10_3181_00379727_91_22171 |
| source | Alma/SFX Local Collection |
| title | Adrenal Corticoid Activities of 2-Methylhydrocortisone Acetate and 2-Methyl-9a-Fluorohydrocortisone Acetate |
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