Interstitial Pneumonia Induced by a Plaque-Type Variant of Mouse Adenovirus 1

Interstitial Pneumonia Induced by a Plaque-Type Variant of Mouse Adenovirus 1

Abstract A plaque-type variant of mouse adenovirus, strain FL was isolated using L-cell monolayer cultures for the plaque assay. Intraperitoneal inoculation of this variant strain was observed to cause death accompanied by hemorrhagic lungs and interstitial pneumonia in adult C3H/HeN mice. Suckling...

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Veröffentlicht in:Proceedings of the Society for Experimental Biology and Medicine 1981-07, Vol.167 (3), p.359-364
Hauptverfasser: Winters, Alvin L., Brown, H. Keith, Carlson, Jeffrey K.
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container_title Proceedings of the Society for Experimental Biology and Medicine
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creator Winters, Alvin L.
Brown, H. Keith
Carlson, Jeffrey K.
description Abstract A plaque-type variant of mouse adenovirus, strain FL was isolated using L-cell monolayer cultures for the plaque assay. Intraperitoneal inoculation of this variant strain was observed to cause death accompanied by hemorrhagic lungs and interstitial pneumonia in adult C3H/HeN mice. Suckling mice developed patchy interstitial pneumonia after intranasal inoculation. Lethal disease was associated with infectivity (LD50 = 5.0 × 106 PFU) and the virus was detected in the lungs by electron microscopy. This plaque-type variant may provide a useful model that heretofore was unavailable for the study of adenovirus pathogenesis in pulmonary disease.
doi_str_mv 10.3181/00379727-167-41179
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title Interstitial Pneumonia Induced by a Plaque-Type Variant of Mouse Adenovirus 1
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