Inhibitory Effect of Cholestyramine on the Absorption of Flufenamic and Mefenamic Acids in Rats 1

Inhibitory Effect of Cholestyramine on the Absorption of Flufenamic and Mefenamic Acids in Rats 1

Summary The binding characteristics of the hypocholesterolemic agent cholestyramine for flufenamic and mefenamic acids were examined in vitro and in vivo. Both drugs strongly interact in vitro with the resin, and the presence of physiologic concentrations of conjugated bile salt anions competitively...

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Veröffentlicht in:Proceedings of the Society for Experimental Biology and Medicine 1974-01, Vol.145 (1), p.93-98
Hauptverfasser: Rosenberg, Howard A., Bates, Theodore R.
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container_title Proceedings of the Society for Experimental Biology and Medicine
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creator Rosenberg, Howard A.
Bates, Theodore R.
description Summary The binding characteristics of the hypocholesterolemic agent cholestyramine for flufenamic and mefenamic acids were examined in vitro and in vivo. Both drugs strongly interact in vitro with the resin, and the presence of physiologic concentrations of conjugated bile salt anions competitively inhibits, but does not totally prevent, this interaction. When flufenamic acid or mefenamic acid and the resin were coadministered orally to fasted rats, a 60-70% reduction in both the rate and extent of absorption of these acids was observed. These results suggest that the therapeutic response elicited by these drugs may be seriously affected by concurrent administration of the resin. Also, the resin may prove to be useful in the treatment of acute fenamate intoxication.
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title Inhibitory Effect of Cholestyramine on the Absorption of Flufenamic and Mefenamic Acids in Rats 1
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