Differential Effects of Phentolamine and Bretylium on Pulmonary Vascular Responses to Norepinephrine and Nerve Stimulation 1
Summary The effects of specific adrenergic blocking agents on pulmonary vascular responses to sympathetic nerve stimulation and norepinephrine were evaluated in the perfused dog lung using a new right heart catheterization procedure which avoids dissection and cannulation of lobar vessels. The incre...
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| Veröffentlicht in: | Proceedings of the Society for Experimental Biology and Medicine 1973-10, Vol.144 (1), p.172-176 |
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| container_issue | 1 |
| container_start_page | 172 |
| container_title | Proceedings of the Society for Experimental Biology and Medicine |
| container_volume | 144 |
| creator | Kadowitz, Philip J. Joiner, Paul D. Hyman, Albert L. |
| description | Summary
The effects of specific adrenergic blocking agents on pulmonary vascular responses to sympathetic nerve stimulation and norepinephrine were evaluated in the perfused dog lung using a new right heart catheterization procedure which avoids dissection and cannulation of lobar vessels. The increase in pulmonary vascular resistance in response to nerve stimulation and norepinephrine but not serotonin was antagonized by phentolamine, an alpha receptor blocking agent. Responses to nerve stimulation but not exogenous norepinephrine were antagonized by bretylium, an adrenergic nerve terminal blocking agent. It is concluded that the pressor response to nerve stimulation is due to activation of alpha receptors by endogenous norepinephrine released from sympathetic nerve endings in the pulmonary blood vessels. |
| doi_str_mv | 10.3181/00379727-144-37550 |
| format | Article |
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The effects of specific adrenergic blocking agents on pulmonary vascular responses to sympathetic nerve stimulation and norepinephrine were evaluated in the perfused dog lung using a new right heart catheterization procedure which avoids dissection and cannulation of lobar vessels. The increase in pulmonary vascular resistance in response to nerve stimulation and norepinephrine but not serotonin was antagonized by phentolamine, an alpha receptor blocking agent. Responses to nerve stimulation but not exogenous norepinephrine were antagonized by bretylium, an adrenergic nerve terminal blocking agent. It is concluded that the pressor response to nerve stimulation is due to activation of alpha receptors by endogenous norepinephrine released from sympathetic nerve endings in the pulmonary blood vessels.</description><identifier>ISSN: 0037-9727</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-144-37550</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>Proceedings of the Society for Experimental Biology and Medicine, 1973-10, Vol.144 (1), p.172-176</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kadowitz, Philip J.</creatorcontrib><creatorcontrib>Joiner, Paul D.</creatorcontrib><creatorcontrib>Hyman, Albert L.</creatorcontrib><title>Differential Effects of Phentolamine and Bretylium on Pulmonary Vascular Responses to Norepinephrine and Nerve Stimulation 1</title><title>Proceedings of the Society for Experimental Biology and Medicine</title><description>Summary
The effects of specific adrenergic blocking agents on pulmonary vascular responses to sympathetic nerve stimulation and norepinephrine were evaluated in the perfused dog lung using a new right heart catheterization procedure which avoids dissection and cannulation of lobar vessels. The increase in pulmonary vascular resistance in response to nerve stimulation and norepinephrine but not serotonin was antagonized by phentolamine, an alpha receptor blocking agent. Responses to nerve stimulation but not exogenous norepinephrine were antagonized by bretylium, an adrenergic nerve terminal blocking agent. It is concluded that the pressor response to nerve stimulation is due to activation of alpha receptors by endogenous norepinephrine released from sympathetic nerve endings in the pulmonary blood vessels.</description><issn>0037-9727</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqVj91KAzEQhYMouP68gFfzArGTptt1b9WKV6WoeBtCnbUp2WTJZIWCD29W7AN4NYfDdwY-IW4U3mp1p2aIummbeSPVYiF1U9d4IipV61rqZdueimoC5ESciwvmPSIucY6V-H50XUeJQnbWw6rkbWaIHWx2pYve9i4Q2PAB94nywbuxhxhgM_o-BpsO8G55O3qb4IV4iIGJIUdYx0RDWQ67dNyvKX0RvGbXFzy78kRdibPOeqbrv3spZk-rt4dnyfaTzD6OKZTaKDSTpDlKmiJpfiX1_xc_xt1aTQ</recordid><startdate>197310</startdate><enddate>197310</enddate><creator>Kadowitz, Philip J.</creator><creator>Joiner, Paul D.</creator><creator>Hyman, Albert L.</creator><general>SAGE Publications</general><scope/></search><sort><creationdate>197310</creationdate><title>Differential Effects of Phentolamine and Bretylium on Pulmonary Vascular Responses to Norepinephrine and Nerve Stimulation 1</title><author>Kadowitz, Philip J. ; Joiner, Paul D. ; Hyman, Albert L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-sage_journals_10_3181_00379727_144_375503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kadowitz, Philip J.</creatorcontrib><creatorcontrib>Joiner, Paul D.</creatorcontrib><creatorcontrib>Hyman, Albert L.</creatorcontrib><jtitle>Proceedings of the Society for Experimental Biology and Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kadowitz, Philip J.</au><au>Joiner, Paul D.</au><au>Hyman, Albert L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Effects of Phentolamine and Bretylium on Pulmonary Vascular Responses to Norepinephrine and Nerve Stimulation 1</atitle><jtitle>Proceedings of the Society for Experimental Biology and Medicine</jtitle><date>1973-10</date><risdate>1973</risdate><volume>144</volume><issue>1</issue><spage>172</spage><epage>176</epage><pages>172-176</pages><issn>0037-9727</issn><eissn>1535-3699</eissn><abstract>Summary
The effects of specific adrenergic blocking agents on pulmonary vascular responses to sympathetic nerve stimulation and norepinephrine were evaluated in the perfused dog lung using a new right heart catheterization procedure which avoids dissection and cannulation of lobar vessels. The increase in pulmonary vascular resistance in response to nerve stimulation and norepinephrine but not serotonin was antagonized by phentolamine, an alpha receptor blocking agent. Responses to nerve stimulation but not exogenous norepinephrine were antagonized by bretylium, an adrenergic nerve terminal blocking agent. It is concluded that the pressor response to nerve stimulation is due to activation of alpha receptors by endogenous norepinephrine released from sympathetic nerve endings in the pulmonary blood vessels.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.3181/00379727-144-37550</doi></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Proceedings of the Society for Experimental Biology and Medicine, 1973-10, Vol.144 (1), p.172-176 |
| issn | 0037-9727 1535-3699 |
| language | eng |
| recordid | cdi_sage_journals_10_3181_00379727_144_37550 |
| source | Alma/SFX Local Collection |
| title | Differential Effects of Phentolamine and Bretylium on Pulmonary Vascular Responses to Norepinephrine and Nerve Stimulation 1 |
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