Biliary Excretion of Chelated Iron.
Summary The iron chelates of Cl-EDDHA, CH3-EDDHA and EDDHA are excreted in the bile unchanged following intravenous and oral administration to rabbits and following intraperitoneal administration to rats. Bile duct ligation results in shunting the excretion into the urine. The metabolic path for the...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-12, Vol.120 (3), p.663-668 |
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| container_end_page | 668 |
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| container_issue | 3 |
| container_start_page | 663 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 120 |
| creator | Haddock, E. P. Zapolski, E. J. Rubin, M. Princiotto, J. V. |
| description | Summary
The iron chelates of Cl-EDDHA, CH3-EDDHA and EDDHA are excreted in the bile unchanged following intravenous and oral administration to rabbits and following intraperitoneal administration to rats. Bile duct ligation results in shunting the excretion into the urine. The metabolic path for these compounds is attributed to their relatively non-polar structure. The absorption of these compounds and Fe CDTA from the intestinal tract without molecular alteration establishes that suitably constructed small molecular weight iron chelates may bypass physiologic mechanisms of oral iron absorption. |
| doi_str_mv | 10.3181/00379727-120-30618 |
| format | Article |
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The iron chelates of Cl-EDDHA, CH3-EDDHA and EDDHA are excreted in the bile unchanged following intravenous and oral administration to rabbits and following intraperitoneal administration to rats. Bile duct ligation results in shunting the excretion into the urine. The metabolic path for these compounds is attributed to their relatively non-polar structure. The absorption of these compounds and Fe CDTA from the intestinal tract without molecular alteration establishes that suitably constructed small molecular weight iron chelates may bypass physiologic mechanisms of oral iron absorption.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-120-30618</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>Experimental biology and medicine (Maywood, N.J.), 1965-12, Vol.120 (3), p.663-668</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-c29b19a2d94e169e4ec7e2896ea9b4b22d6ae6d1eedf045b138134c8ef7354c03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Haddock, E. P.</creatorcontrib><creatorcontrib>Zapolski, E. J.</creatorcontrib><creatorcontrib>Rubin, M.</creatorcontrib><creatorcontrib>Princiotto, J. V.</creatorcontrib><title>Biliary Excretion of Chelated Iron.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><description>Summary
The iron chelates of Cl-EDDHA, CH3-EDDHA and EDDHA are excreted in the bile unchanged following intravenous and oral administration to rabbits and following intraperitoneal administration to rats. Bile duct ligation results in shunting the excretion into the urine. The metabolic path for these compounds is attributed to their relatively non-polar structure. The absorption of these compounds and Fe CDTA from the intestinal tract without molecular alteration establishes that suitably constructed small molecular weight iron chelates may bypass physiologic mechanisms of oral iron absorption.</description><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><recordid>eNp9jz1PwzAURS0EEqHwB5giMbv1sx1_jBCVUqkSSztbjvMCqUKC7CDBvyehsLK8t9xzdQ8ht8CWAgysGBPaaq4pcEYFU2DOSAaFKKhQ1p6TbA7QOXFJrlI6MgaF5iojdw9t1_r4la8_Q8SxHfp8aPLyFTs_Yp1v49Avr8lF47uEN79_QQ6P6335RHfPm215v6OBGz1O11ZgPa-tRFAWJQaN3FiF3lay4rxWHlUNiHXDZFGBMCBkMNhoUcjAxILwU2-IQ0oRG_ce27dpnAPmZk33p-kmTfejOUGrE5T8C7rj8BH7aeN_xDcUY1F9</recordid><startdate>196512</startdate><enddate>196512</enddate><creator>Haddock, E. P.</creator><creator>Zapolski, E. J.</creator><creator>Rubin, M.</creator><creator>Princiotto, J. V.</creator><general>SAGE Publications</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196512</creationdate><title>Biliary Excretion of Chelated Iron.</title><author>Haddock, E. P. ; Zapolski, E. J. ; Rubin, M. ; Princiotto, J. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-c29b19a2d94e169e4ec7e2896ea9b4b22d6ae6d1eedf045b138134c8ef7354c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haddock, E. P.</creatorcontrib><creatorcontrib>Zapolski, E. J.</creatorcontrib><creatorcontrib>Rubin, M.</creatorcontrib><creatorcontrib>Princiotto, J. V.</creatorcontrib><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haddock, E. P.</au><au>Zapolski, E. J.</au><au>Rubin, M.</au><au>Princiotto, J. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biliary Excretion of Chelated Iron.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><date>1965-12</date><risdate>1965</risdate><volume>120</volume><issue>3</issue><spage>663</spage><epage>668</epage><pages>663-668</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
The iron chelates of Cl-EDDHA, CH3-EDDHA and EDDHA are excreted in the bile unchanged following intravenous and oral administration to rabbits and following intraperitoneal administration to rats. Bile duct ligation results in shunting the excretion into the urine. The metabolic path for these compounds is attributed to their relatively non-polar structure. The absorption of these compounds and Fe CDTA from the intestinal tract without molecular alteration establishes that suitably constructed small molecular weight iron chelates may bypass physiologic mechanisms of oral iron absorption.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.3181/00379727-120-30618</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1965-12, Vol.120 (3), p.663-668 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_sage_journals_10_3181_00379727_120_30618 |
| source | Alma/SFX Local Collection |
| title | Biliary Excretion of Chelated Iron. |
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