Synthesis and biological activity of new 2,4,6-trisubstituted triazines as potential phosphoinositide 3-kinase inhibitors

Twenty-five novel 2,4,6-trisubstituted triazines were synthesized and biologically evaluated. Most of the compounds synthesized showed good antiproliferative activity against HCT-116 and MCF-7. Compounds B18 and B19 showed the best antiproliferative activity. Further study showed B18 and B19 inhibit...

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Veröffentlicht in:	Journal of chemical research 2020-07, Vol.44 (7-8), p.393-402, Article 1747519820904844
Hauptverfasser:	Xin, Minhang, Wang, Hui-Yan, Zhang, Hao, Shen, Ying, Zhang, San-Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Chemistry Chemistry, Multidisciplinary Kinases Physical Sciences Rapamycin Science & Technology Synthesis
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