YAP activation in melanoma contributes to anoikis resistance and metastasis

Melanoma is inherently heterogeneous, providing resistance to apoptosis. Anoikis resistance is a hallmark feature of metastatic melanoma to escape apoptosis when cells lose contact with adjacent cells or extracellular matrix. The yes-associated protein transcription co-activator is the effector of H...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2021-04, Vol.246 (8), p.888-896
Hauptverfasser:	Zhao, Bei, Xie, Jun, Zhou, Xiyuan, Zhang, Lixia, Cheng, Xiankui, Liang, Chenglin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Anoikis Cell Line, Tumor Heterografts Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - secondary Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mice Mice, SCID Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - metabolism Neoplasm Metastasis Neoplasm Transplantation Original Research Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Transcription Factors - genetics Transcription Factors - metabolism YAP-Signaling Proteins
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