Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway

Rutin is one of the flavonoids found in fruits and vegetables. Recent reports have revealed that rutin is a major player in proliferation and bone development. However, data on how rutin regulates the proliferation of periodontal ligament stem cells (PDLSCs), as well as the differentiation of osteog...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2020-03, Vol.245 (6), p.552-561, Article 1535370220903463
Hauptverfasser:	Zhao, Bin, Xiong, Yixuan, Zhang, Yunpeng, Jia, Linglu, Zhang, Wenjing, Xu, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Cells, Cultured Chromones - pharmacology Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Life Sciences & Biomedicine Medicine, Research & Experimental Morpholines - pharmacology Original Research Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteogenesis Periodontal Ligament - cytology Phosphatidylinositol 3-Kinases - metabolism Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - metabolism Receptors, Estrogen - metabolism Receptors, G-Protein-Coupled - metabolism Research & Experimental Medicine Rutin - pharmacology Science & Technology Signal Transduction TOR Serine-Threonine Kinases - metabolism
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