Amelioration of AlCl3-induced Memory Loss in the Rats by an Aqueous Extract of Guduchi, a Medhya Rasayana
Background In ayurvedic practice, the Guduchi (Tinospora cordifolia (Willd.) Miers) stem is used as a Medhya drug for its beneficial effects on memory improvement. Objectives The current study was planned to explore the Medhya properties of the Guduchi stem extract by observing its ameliorating effe...
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| Veröffentlicht in: | Pharmacognosy Magazine 2023-06, Vol.19 (2), p.231-243 |
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| creator | Jamadagni, Shrirang B. Ghadge, Pooja M. Tambe, Mukul S. Srinivasan, Marimuthu Prasad, Goli Penchala Jamadagni, Pallavi S. Prasad, Shyam Baboo Pawar, Sharad D. Gurav, Arun M. Gaidhani, Sudesh N. Kumar, Y. R. Sanjay Srikanth, Narayanam |
| description | Background
In ayurvedic practice, the Guduchi (Tinospora cordifolia (Willd.) Miers) stem is used as a Medhya drug for its beneficial effects on memory improvement.
Objectives
The current study was planned to explore the Medhya properties of the Guduchi stem extract by observing its ameliorating effect on AlCl3-induced neurotoxicity in rats that acted as a chronic model of memory loss.
Materials and Methods
The aqueous extract of the Guduchi stem was prepared per the Ayurvedic Pharmacopoeia of India and administered to the AlCl3-treated Wistar rats for 42 days. The biochemical assessment of the brain tissues of the treated animals was done by the acetylcholinesterase (AChE) inhibition assay, protein expression, and oxidative stress assays, namely lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase assay. The neurobehavioral assessment was done using the elevated plus maze (EPM) test.
Results
The EPM test revealed that treatment with Guduchi extract showed marked improvement of memory status in rats along with reduced oxidative stress, and a marked modulation of the AChE inhibition and expression of AChE tubulin proteins.
Conclusion
The results substantiate the Medhya properties of the Guduchi. Detailed investigations are required to be carried out to explore the precise mechanism of the neuroprotective action of the Guduchi stem extract against the AlCl3-induced neurotoxicity in rats. |
| doi_str_mv | 10.1177/09731296221145063 |
| format | Article |
| fullrecord | <record><control><sourceid>sage</sourceid><recordid>TN_cdi_sage_journals_10_1177_09731296221145063</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_09731296221145063</sage_id><sourcerecordid>10.1177_09731296221145063</sourcerecordid><originalsourceid>FETCH-LOGICAL-s167t-f24756a371c8a7b436ae7eb130fff62182c4e34ed8ca4613fb202911c80decfa3</originalsourceid><addsrcrecordid>eNplkMFKxDAQhoMouK4-gLc8gF0zSZq0x1LWVagIoucybRPbpdtgk4J9e1v15ml-hu-bgZ-QW2A7AK3vWaoF8FRxDiBjpsQZ2Sw7FUmm-PlPFtEKXJIr74-MxQkwvSFddjJ950YMnRuoszTr815E3dBMtWnoszm5caaF8552Aw2toa8YPK1migPNPifjJk_3X2HEOqz6YVrEtrujuLhNO-PCe5xxwGtyYbH35uZvbsn7w_4tf4yKl8NTnhWRB6VDZLnUsUKhoU5QV1IoNNpUIJi1VnFIeC2NkKZJapQKhK044yksNGtMbVFsye73rscPUx7dNA7LuxJYuRZV_itKfAP_pVp7</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Amelioration of AlCl3-induced Memory Loss in the Rats by an Aqueous Extract of Guduchi, a Medhya Rasayana</title><source>Sage Journals GOLD Open Access 2024</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Jamadagni, Shrirang B. ; Ghadge, Pooja M. ; Tambe, Mukul S. ; Srinivasan, Marimuthu ; Prasad, Goli Penchala ; Jamadagni, Pallavi S. ; Prasad, Shyam Baboo ; Pawar, Sharad D. ; Gurav, Arun M. ; Gaidhani, Sudesh N. ; Kumar, Y. R. Sanjay ; Srikanth, Narayanam</creator><creatorcontrib>Jamadagni, Shrirang B. ; Ghadge, Pooja M. ; Tambe, Mukul S. ; Srinivasan, Marimuthu ; Prasad, Goli Penchala ; Jamadagni, Pallavi S. ; Prasad, Shyam Baboo ; Pawar, Sharad D. ; Gurav, Arun M. ; Gaidhani, Sudesh N. ; Kumar, Y. R. Sanjay ; Srikanth, Narayanam</creatorcontrib><description>Background
In ayurvedic practice, the Guduchi (Tinospora cordifolia (Willd.) Miers) stem is used as a Medhya drug for its beneficial effects on memory improvement.
Objectives
The current study was planned to explore the Medhya properties of the Guduchi stem extract by observing its ameliorating effect on AlCl3-induced neurotoxicity in rats that acted as a chronic model of memory loss.
Materials and Methods
The aqueous extract of the Guduchi stem was prepared per the Ayurvedic Pharmacopoeia of India and administered to the AlCl3-treated Wistar rats for 42 days. The biochemical assessment of the brain tissues of the treated animals was done by the acetylcholinesterase (AChE) inhibition assay, protein expression, and oxidative stress assays, namely lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase assay. The neurobehavioral assessment was done using the elevated plus maze (EPM) test.
Results
The EPM test revealed that treatment with Guduchi extract showed marked improvement of memory status in rats along with reduced oxidative stress, and a marked modulation of the AChE inhibition and expression of AChE tubulin proteins.
Conclusion
The results substantiate the Medhya properties of the Guduchi. Detailed investigations are required to be carried out to explore the precise mechanism of the neuroprotective action of the Guduchi stem extract against the AlCl3-induced neurotoxicity in rats.</description><identifier>ISSN: 0973-1296</identifier><identifier>EISSN: 0976-4062</identifier><identifier>DOI: 10.1177/09731296221145063</identifier><language>eng</language><publisher>New Delhi, India: SAGE Publications</publisher><ispartof>Pharmacognosy Magazine, 2023-06, Vol.19 (2), p.231-243</ispartof><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/09731296221145063$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/09731296221145063$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids></links><search><creatorcontrib>Jamadagni, Shrirang B.</creatorcontrib><creatorcontrib>Ghadge, Pooja M.</creatorcontrib><creatorcontrib>Tambe, Mukul S.</creatorcontrib><creatorcontrib>Srinivasan, Marimuthu</creatorcontrib><creatorcontrib>Prasad, Goli Penchala</creatorcontrib><creatorcontrib>Jamadagni, Pallavi S.</creatorcontrib><creatorcontrib>Prasad, Shyam Baboo</creatorcontrib><creatorcontrib>Pawar, Sharad D.</creatorcontrib><creatorcontrib>Gurav, Arun M.</creatorcontrib><creatorcontrib>Gaidhani, Sudesh N.</creatorcontrib><creatorcontrib>Kumar, Y. R. Sanjay</creatorcontrib><creatorcontrib>Srikanth, Narayanam</creatorcontrib><title>Amelioration of AlCl3-induced Memory Loss in the Rats by an Aqueous Extract of Guduchi, a Medhya Rasayana</title><title>Pharmacognosy Magazine</title><description>Background
In ayurvedic practice, the Guduchi (Tinospora cordifolia (Willd.) Miers) stem is used as a Medhya drug for its beneficial effects on memory improvement.
Objectives
The current study was planned to explore the Medhya properties of the Guduchi stem extract by observing its ameliorating effect on AlCl3-induced neurotoxicity in rats that acted as a chronic model of memory loss.
Materials and Methods
The aqueous extract of the Guduchi stem was prepared per the Ayurvedic Pharmacopoeia of India and administered to the AlCl3-treated Wistar rats for 42 days. The biochemical assessment of the brain tissues of the treated animals was done by the acetylcholinesterase (AChE) inhibition assay, protein expression, and oxidative stress assays, namely lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase assay. The neurobehavioral assessment was done using the elevated plus maze (EPM) test.
Results
The EPM test revealed that treatment with Guduchi extract showed marked improvement of memory status in rats along with reduced oxidative stress, and a marked modulation of the AChE inhibition and expression of AChE tubulin proteins.
Conclusion
The results substantiate the Medhya properties of the Guduchi. Detailed investigations are required to be carried out to explore the precise mechanism of the neuroprotective action of the Guduchi stem extract against the AlCl3-induced neurotoxicity in rats.</description><issn>0973-1296</issn><issn>0976-4062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNplkMFKxDAQhoMouK4-gLc8gF0zSZq0x1LWVagIoucybRPbpdtgk4J9e1v15ml-hu-bgZ-QW2A7AK3vWaoF8FRxDiBjpsQZ2Sw7FUmm-PlPFtEKXJIr74-MxQkwvSFddjJ950YMnRuoszTr815E3dBMtWnoszm5caaF8552Aw2toa8YPK1migPNPifjJk_3X2HEOqz6YVrEtrujuLhNO-PCe5xxwGtyYbH35uZvbsn7w_4tf4yKl8NTnhWRB6VDZLnUsUKhoU5QV1IoNNpUIJi1VnFIeC2NkKZJapQKhK044yksNGtMbVFsye73rscPUx7dNA7LuxJYuRZV_itKfAP_pVp7</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Jamadagni, Shrirang B.</creator><creator>Ghadge, Pooja M.</creator><creator>Tambe, Mukul S.</creator><creator>Srinivasan, Marimuthu</creator><creator>Prasad, Goli Penchala</creator><creator>Jamadagni, Pallavi S.</creator><creator>Prasad, Shyam Baboo</creator><creator>Pawar, Sharad D.</creator><creator>Gurav, Arun M.</creator><creator>Gaidhani, Sudesh N.</creator><creator>Kumar, Y. R. Sanjay</creator><creator>Srikanth, Narayanam</creator><general>SAGE Publications</general><scope>AFRWT</scope></search><sort><creationdate>202306</creationdate><title>Amelioration of AlCl3-induced Memory Loss in the Rats by an Aqueous Extract of Guduchi, a Medhya Rasayana</title><author>Jamadagni, Shrirang B. ; Ghadge, Pooja M. ; Tambe, Mukul S. ; Srinivasan, Marimuthu ; Prasad, Goli Penchala ; Jamadagni, Pallavi S. ; Prasad, Shyam Baboo ; Pawar, Sharad D. ; Gurav, Arun M. ; Gaidhani, Sudesh N. ; Kumar, Y. R. Sanjay ; Srikanth, Narayanam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-s167t-f24756a371c8a7b436ae7eb130fff62182c4e34ed8ca4613fb202911c80decfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jamadagni, Shrirang B.</creatorcontrib><creatorcontrib>Ghadge, Pooja M.</creatorcontrib><creatorcontrib>Tambe, Mukul S.</creatorcontrib><creatorcontrib>Srinivasan, Marimuthu</creatorcontrib><creatorcontrib>Prasad, Goli Penchala</creatorcontrib><creatorcontrib>Jamadagni, Pallavi S.</creatorcontrib><creatorcontrib>Prasad, Shyam Baboo</creatorcontrib><creatorcontrib>Pawar, Sharad D.</creatorcontrib><creatorcontrib>Gurav, Arun M.</creatorcontrib><creatorcontrib>Gaidhani, Sudesh N.</creatorcontrib><creatorcontrib>Kumar, Y. R. Sanjay</creatorcontrib><creatorcontrib>Srikanth, Narayanam</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><jtitle>Pharmacognosy Magazine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jamadagni, Shrirang B.</au><au>Ghadge, Pooja M.</au><au>Tambe, Mukul S.</au><au>Srinivasan, Marimuthu</au><au>Prasad, Goli Penchala</au><au>Jamadagni, Pallavi S.</au><au>Prasad, Shyam Baboo</au><au>Pawar, Sharad D.</au><au>Gurav, Arun M.</au><au>Gaidhani, Sudesh N.</au><au>Kumar, Y. R. Sanjay</au><au>Srikanth, Narayanam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amelioration of AlCl3-induced Memory Loss in the Rats by an Aqueous Extract of Guduchi, a Medhya Rasayana</atitle><jtitle>Pharmacognosy Magazine</jtitle><date>2023-06</date><risdate>2023</risdate><volume>19</volume><issue>2</issue><spage>231</spage><epage>243</epage><pages>231-243</pages><issn>0973-1296</issn><eissn>0976-4062</eissn><abstract>Background
In ayurvedic practice, the Guduchi (Tinospora cordifolia (Willd.) Miers) stem is used as a Medhya drug for its beneficial effects on memory improvement.
Objectives
The current study was planned to explore the Medhya properties of the Guduchi stem extract by observing its ameliorating effect on AlCl3-induced neurotoxicity in rats that acted as a chronic model of memory loss.
Materials and Methods
The aqueous extract of the Guduchi stem was prepared per the Ayurvedic Pharmacopoeia of India and administered to the AlCl3-treated Wistar rats for 42 days. The biochemical assessment of the brain tissues of the treated animals was done by the acetylcholinesterase (AChE) inhibition assay, protein expression, and oxidative stress assays, namely lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase assay. The neurobehavioral assessment was done using the elevated plus maze (EPM) test.
Results
The EPM test revealed that treatment with Guduchi extract showed marked improvement of memory status in rats along with reduced oxidative stress, and a marked modulation of the AChE inhibition and expression of AChE tubulin proteins.
Conclusion
The results substantiate the Medhya properties of the Guduchi. Detailed investigations are required to be carried out to explore the precise mechanism of the neuroprotective action of the Guduchi stem extract against the AlCl3-induced neurotoxicity in rats.</abstract><cop>New Delhi, India</cop><pub>SAGE Publications</pub><doi>10.1177/09731296221145063</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| title | Amelioration of AlCl3-induced Memory Loss in the Rats by an Aqueous Extract of Guduchi, a Medhya Rasayana |
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