Factors Modifying Contrast Media Induced Fibrillation

Factors effecting contrast media induced ventricular fibrillation were studied in anesthetized dogs using contact time as the measured parameter. Injections of meglumine/sodium diatrizoate (370 mg I/ml) were made into the right coronary artery at 0.4 ml/s until fibrillation occurred. A contrast medi...

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Veröffentlicht in:Acta Radiologica. Diagnosis 1985-11, Vol.26 (6), p.771-775
Hauptverfasser: Morris, T. W., Ciaravino, V., Sahler, L. G., Cioffi, B.
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container_issue 6
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container_title Acta Radiologica. Diagnosis
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creator Morris, T. W.
Ciaravino, V.
Sahler, L. G.
Cioffi, B.
description Factors effecting contrast media induced ventricular fibrillation were studied in anesthetized dogs using contact time as the measured parameter. Injections of meglumine/sodium diatrizoate (370 mg I/ml) were made into the right coronary artery at 0.4 ml/s until fibrillation occurred. A contrast medium containing calcium chelators was found to produce fibrillation in a significantly shorter contact time than a similar medium without calcium chelators. Pre-treatment by the cardiac glycoside, ouabain, increased the contact time for fibrillation as did the production of a sub-acute infarction in the left coronary artery and a previous fibrillation and resuscitation. The data suggest that calcium binding additives increase the risk of fibrillation while pre-treatment with cardiac glycosides, the presence of stable infarcts in the non-injected areas, or a previous fibrillation and resuscitation do not increase risk.
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subjects Animals
Biological and medical sciences
Calcium - metabolism
Chelating Agents - therapeutic use
Contrast Media - administration & dosage
Contrast Media - adverse effects
Contrast media. Radiopharmaceuticals
Diatrizoate - adverse effects
Diatrizoate Meglumine - adverse effects
Dogs
Drug Combinations - adverse effects
Medical sciences
Myocardial Infarction - chemically induced
Ouabain - therapeutic use
Pharmacology. Drug treatments
Risk
Time Factors
Ventricular Fibrillation - chemically induced
title Factors Modifying Contrast Media Induced Fibrillation
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