Canine Model of Contrast Medium Induced Fibrillation
The injection of radiocontrast media into coronary arteries will produce a low incidence of ventricular fibrillation. This study establishes the injection duration (or contact time) required to produce fibrillation during right coronary angiography in dogs using a 370 mg I/ml, meglumine/sodium diatr...
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| Veröffentlicht in: | Acta Radiologica. Diagnosis 1985-07, Vol.26 (4), p.471-475 |
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| container_end_page | 475 |
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| container_issue | 4 |
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| container_title | Acta Radiologica. Diagnosis |
| container_volume | 26 |
| creator | Morris, T. W. Sahler, L. G. Harnish, P. P. Violante, M. R. |
| description | The injection of radiocontrast media into coronary arteries will produce a low incidence of ventricular fibrillation. This study establishes the injection duration (or contact time) required to produce fibrillation during right coronary angiography in dogs using a 370 mg I/ml, meglumine/sodium diatrizoate formulation (Renografin 76, Squibb). The mean contact time required to induce fibrillation was 18.8±5.8 seconds for 66 injections in 47 dogs. Prolonged ischemia of greater than 170 s did not produce either fibrillation or arrhythmias, therefore fibrillation is caused by properties of the media. The contact time was not significantly influenced by test injections and was not significantly different in repeated experiments. The canine contact time model of contrast media induced ventricular fibrillation is reproducible and will facilitate the study of risk factors that increase the possibility of fibrillation. |
| doi_str_mv | 10.1177/028418518502600419 |
| format | Article |
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The canine contact time model of contrast media induced ventricular fibrillation is reproducible and will facilitate the study of risk factors that increase the possibility of fibrillation.</description><identifier>ISSN: 0567-8056</identifier><identifier>EISSN: 1600-0455</identifier><identifier>DOI: 10.1177/028418518502600419</identifier><identifier>PMID: 4050530</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Angiocardiography - adverse effects ; Angiocardiography - methods ; Animals ; Biological and medical sciences ; Contrast Media - toxicity ; Coronary Disease - etiology ; Disease Models, Animal ; Dogs ; Drug toxicity and drugs side effects treatment ; Electrocardiography ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Time Factors ; Ventricular Fibrillation - chemically induced ; Ventricular Fibrillation - physiopathology</subject><ispartof>Acta Radiologica. 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W.</creatorcontrib><creatorcontrib>Sahler, L. G.</creatorcontrib><creatorcontrib>Harnish, P. P.</creatorcontrib><creatorcontrib>Violante, M. R.</creatorcontrib><title>Canine Model of Contrast Medium Induced Fibrillation</title><title>Acta Radiologica. Diagnosis</title><addtitle>Acta Radiol Diagn (Stockh)</addtitle><description>The injection of radiocontrast media into coronary arteries will produce a low incidence of ventricular fibrillation. This study establishes the injection duration (or contact time) required to produce fibrillation during right coronary angiography in dogs using a 370 mg I/ml, meglumine/sodium diatrizoate formulation (Renografin 76, Squibb). The mean contact time required to induce fibrillation was 18.8±5.8 seconds for 66 injections in 47 dogs. Prolonged ischemia of greater than 170 s did not produce either fibrillation or arrhythmias, therefore fibrillation is caused by properties of the media. The contact time was not significantly influenced by test injections and was not significantly different in repeated experiments. The canine contact time model of contrast media induced ventricular fibrillation is reproducible and will facilitate the study of risk factors that increase the possibility of fibrillation.</description><subject>Angiocardiography - adverse effects</subject><subject>Angiocardiography - methods</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Contrast Media - toxicity</subject><subject>Coronary Disease - etiology</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Electrocardiography</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><subject>Ventricular Fibrillation - chemically induced</subject><subject>Ventricular Fibrillation - physiopathology</subject><issn>0567-8056</issn><issn>1600-0455</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UE1Lw0AQXUSptfoHBCEHr7GzX9ndowSrhRYveg77FUlJN2U3OfjvXWnpRRCGmYH33gzvIXSP4QljIZZAJMOS5wJSATCsLtAc560ExvklmgOvRClzv0Y3Ke0AMBEcz9CMAQdOYY5YrUMXfLEdnO-LoS3qIYxRp7HYetdN-2Id3GS9K1adiV3f67Ebwi26anWf_N1pLtDn6uWjfis376_r-nlTWkbpWOpWOOMcp4pSwyklVBLnvBaWMAlKVWAqLgSjxCvtVCUJKMKF5dZw6cHQBSLHuzYOKUXfNofY7XX8bjA0vwk0fxPIooej6DCZvXdnyclyxh9PuE5W923UwXbpTJNMEKhwpi2PtKS_fLMbphiy1f8e_wB8TW3g</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Morris, T. W.</creator><creator>Sahler, L. G.</creator><creator>Harnish, P. P.</creator><creator>Violante, M. 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R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-af7dbdd53933b5332382ddea7c24809960b6577432e9ad968209257c5cb58e0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Angiocardiography - adverse effects</topic><topic>Angiocardiography - methods</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Contrast Media - toxicity</topic><topic>Coronary Disease - etiology</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electrocardiography</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><topic>Ventricular Fibrillation - chemically induced</topic><topic>Ventricular Fibrillation - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morris, T. W.</creatorcontrib><creatorcontrib>Sahler, L. G.</creatorcontrib><creatorcontrib>Harnish, P. P.</creatorcontrib><creatorcontrib>Violante, M. R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta Radiologica. Diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morris, T. W.</au><au>Sahler, L. G.</au><au>Harnish, P. P.</au><au>Violante, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Canine Model of Contrast Medium Induced Fibrillation</atitle><jtitle>Acta Radiologica. Diagnosis</jtitle><addtitle>Acta Radiol Diagn (Stockh)</addtitle><date>1985-07</date><risdate>1985</risdate><volume>26</volume><issue>4</issue><spage>471</spage><epage>475</epage><pages>471-475</pages><issn>0567-8056</issn><eissn>1600-0455</eissn><abstract>The injection of radiocontrast media into coronary arteries will produce a low incidence of ventricular fibrillation. This study establishes the injection duration (or contact time) required to produce fibrillation during right coronary angiography in dogs using a 370 mg I/ml, meglumine/sodium diatrizoate formulation (Renografin 76, Squibb). The mean contact time required to induce fibrillation was 18.8±5.8 seconds for 66 injections in 47 dogs. Prolonged ischemia of greater than 170 s did not produce either fibrillation or arrhythmias, therefore fibrillation is caused by properties of the media. The contact time was not significantly influenced by test injections and was not significantly different in repeated experiments. The canine contact time model of contrast media induced ventricular fibrillation is reproducible and will facilitate the study of risk factors that increase the possibility of fibrillation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>4050530</pmid><doi>10.1177/028418518502600419</doi><tpages>5</tpages></addata></record> |
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| ispartof | Acta Radiologica. Diagnosis, 1985-07, Vol.26 (4), p.471-475 |
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| source | Taylor & Francis Online; MEDLINE |
| subjects | Angiocardiography - adverse effects Angiocardiography - methods Animals Biological and medical sciences Contrast Media - toxicity Coronary Disease - etiology Disease Models, Animal Dogs Drug toxicity and drugs side effects treatment Electrocardiography Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Time Factors Ventricular Fibrillation - chemically induced Ventricular Fibrillation - physiopathology |
| title | Canine Model of Contrast Medium Induced Fibrillation |
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