Myocardial Accumulation of 99Tcm-Pyrophosphate and 99Tcm-Gluconate Compared with Morphologic Findings in Daunorubicin Treated Rabbits
In long-term daunorubicin treated rabbits increased myocardial accumulation of 99Tcm-pyrophosphate and 99Tcm-gluconate of a varying degree were recorded, visible at gamma camera examination in more than half of the animals. Chronic cardiomyopathy morphologically and topographically different from th...
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| Veröffentlicht in: | Acta Radiologica. Diagnosis 1982, Vol.23 (5), p.463-470 |
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| container_title | Acta Radiologica. Diagnosis |
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| creator | Ahlberg, N. E. Paul Isberg, B. Rajs, J. Svahn, U. |
| description | In long-term daunorubicin treated rabbits increased myocardial accumulation of 99Tcm-pyrophosphate and 99Tcm-gluconate of a varying degree were recorded, visible at gamma camera examination in more than half of the animals. Chronic cardiomyopathy morphologically and topographically different from the ischemic myocardial injury was demonstrated in most animals at light microscopic examination. The myocardial abnormalities were classified in qualitative and quantitative scores and compared with the degree of isotope accumulation. The rabbits receiving a large single dose of daunorubicin had slightly increased isotope accumulation in the myocardium but no histopathologic changes. |
| doi_str_mv | 10.1177/028418518202300505 |
| format | Article |
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The rabbits receiving a large single dose of daunorubicin had slightly increased isotope accumulation in the myocardium but no histopathologic changes.</description><identifier>ISSN: 0567-8056</identifier><identifier>EISSN: 1600-0455</identifier><identifier>DOI: 10.1177/028418518202300505</identifier><identifier>PMID: 6297245</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Cardiomyopathies - chemically induced ; Cardiomyopathies - diagnostic imaging ; Cardiomyopathies - pathology ; Daunorubicin - adverse effects ; Diphosphates - metabolism ; Drug Administration Schedule ; Female ; Gluconates - metabolism ; Heart - drug effects ; Male ; Myocardium - metabolism ; Myocardium - pathology ; Organ Size ; Organotechnetium Compounds ; Rabbits ; Radionuclide Imaging ; Technetium - metabolism ; Technetium Tc 99m Pyrophosphate</subject><ispartof>Acta Radiologica. 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The rabbits receiving a large single dose of daunorubicin had slightly increased isotope accumulation in the myocardium but no histopathologic changes.</description><subject>Animals</subject><subject>Cardiomyopathies - chemically induced</subject><subject>Cardiomyopathies - diagnostic imaging</subject><subject>Cardiomyopathies - pathology</subject><subject>Daunorubicin - adverse effects</subject><subject>Diphosphates - metabolism</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Gluconates - metabolism</subject><subject>Heart - drug effects</subject><subject>Male</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Organ Size</subject><subject>Organotechnetium Compounds</subject><subject>Rabbits</subject><subject>Radionuclide Imaging</subject><subject>Technetium - metabolism</subject><subject>Technetium Tc 99m Pyrophosphate</subject><issn>0567-8056</issn><issn>1600-0455</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkN9KwzAUxoMoc05fQBDyAnX52zSXY7opbCjS-5Im6ZbRJiVtkT2A772O7c6bczjfd87H4QfAM0avGAsxRyRjOOM4I4hQhDjiN2CKU4QSxDi_BVPEU5FkY70HD113QAgTwfEETFIiBWF8Cv62x6BVNE7VcKH10Ay16l3wMFRQylw3yfcxhnYfunaveguVN1d9XQ86-LO2DE2rojXw1_V7uA1xXK_Dzmm4ct44v-ug8_BNDT7EoXR6HPJox0sDf1RZur57BHeVqjv7dO0zkK_e8-VHsvlafy4Xm6SVlCdppTXlhHOmUEkxloZJljJrBKOC60oyahhLMUalHcFoQrNUaWzJWZRc0Bl4ucS2Q9lYU7TRNSoeiyuN0Z9f_E7tbHEIQ_TjNwVGxRl38R83PQH7XG_H</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Ahlberg, N. 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E.</creatorcontrib><creatorcontrib>Paul</creatorcontrib><creatorcontrib>Isberg, B.</creatorcontrib><creatorcontrib>Rajs, J.</creatorcontrib><creatorcontrib>Svahn, U.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Acta Radiologica. Diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahlberg, N. E.</au><au>Paul</au><au>Isberg, B.</au><au>Rajs, J.</au><au>Svahn, U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial Accumulation of 99Tcm-Pyrophosphate and 99Tcm-Gluconate Compared with Morphologic Findings in Daunorubicin Treated Rabbits</atitle><jtitle>Acta Radiologica. Diagnosis</jtitle><addtitle>Acta Radiol Diagn (Stockh)</addtitle><date>1982</date><risdate>1982</risdate><volume>23</volume><issue>5</issue><spage>463</spage><epage>470</epage><pages>463-470</pages><issn>0567-8056</issn><eissn>1600-0455</eissn><abstract>In long-term daunorubicin treated rabbits increased myocardial accumulation of 99Tcm-pyrophosphate and 99Tcm-gluconate of a varying degree were recorded, visible at gamma camera examination in more than half of the animals. Chronic cardiomyopathy morphologically and topographically different from the ischemic myocardial injury was demonstrated in most animals at light microscopic examination. The myocardial abnormalities were classified in qualitative and quantitative scores and compared with the degree of isotope accumulation. 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| fulltext | fulltext |
| identifier | ISSN: 0567-8056 |
| ispartof | Acta Radiologica. Diagnosis, 1982, Vol.23 (5), p.463-470 |
| issn | 0567-8056 1600-0455 |
| language | eng |
| recordid | cdi_sage_journals_10_1177_028418518202300505 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | Animals Cardiomyopathies - chemically induced Cardiomyopathies - diagnostic imaging Cardiomyopathies - pathology Daunorubicin - adverse effects Diphosphates - metabolism Drug Administration Schedule Female Gluconates - metabolism Heart - drug effects Male Myocardium - metabolism Myocardium - pathology Organ Size Organotechnetium Compounds Rabbits Radionuclide Imaging Technetium - metabolism Technetium Tc 99m Pyrophosphate |
| title | Myocardial Accumulation of 99Tcm-Pyrophosphate and 99Tcm-Gluconate Compared with Morphologic Findings in Daunorubicin Treated Rabbits |
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