Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels

Sex is an important determinant of brain microvessels (MVs) function and susceptibility to cerebrovascular and neurological diseases, but underlying mechanisms are unclear. Using high throughput RNA sequencing analysis, we examined differentially expressed (DE) genes in brain MVs from young, male, a...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2021-09, Vol.41 (9), p.2311-2328, Article 0271678
Hauptverfasser:	Chandra, Partha K, Cikic, Sinisa, Baddoo, Melody C, Rutkai, Ibolya, Guidry, Jessie J, Flemington, Erik K, Katakam, Prasad VG, Busija, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - physiopathology Endocrinology & Metabolism Female Gene Expression Profiling - methods Gene Expression Regulation - genetics Hematology Life Sciences & Biomedicine Male Microvessels - physiopathology Neurosciences Neurosciences & Neurology Original Proteomics - methods Rats Rats, Sprague-Dawley Science & Technology Sex Characteristics
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Zusammenfassung:	Sex is an important determinant of brain microvessels (MVs) function and susceptibility to cerebrovascular and neurological diseases, but underlying mechanisms are unclear. Using high throughput RNA sequencing analysis, we examined differentially expressed (DE) genes in brain MVs from young, male, and female rats. Bioinformatics analysis of the 23,786 identified genes indicates that 298 (1.2%) genes were DE using False Discovery Rate criteria (FDR; p
ISSN:	0271-678X 1559-7016
DOI:	10.1177/0271678X21999553