The Histology and Development of Hepatic Nodules and Carcinoma in C3H/He and C57BL/6 Mice Following Chronic Phenobarbitone Administration

Male C3H/He and C57BL/6 mice were given diets containing sodium phenobarbitone (PB) to allow a daily intake of 85 mg/kg. Control and treated animals were killed at 5, 30, 40, 60, and 80 wk. Other mice were killed in extremis or at the end of the respective experiments: 91 wk for C3H/He and 100 wk fo...

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