Genotype-Phenotype Effects of Bmpr2 Mutations on Disease Severity in Mouse Models of Pulmonary Hypertension

More than 350 mutations in the type-2 BMP (bone morphogenetic protein) receptor, BMPR2, have been identified in patients with heritable pulmonary arterial hypertension (HPAH). However, only 30% of BMPR2 mutation carriers develop PAH, and we cannot predict which of these carriers will develop clinica...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Pulmonary circulation 2016-12, Vol.6 (4), p.597-607
Hauptverfasser:	Frump, Andrea L., Datta, Arunima, Ghose, Sampa, West, James, de Caestecker, Mark P.
Format:	Artikel
Sprache:	eng
Schlagworte:	bone morphogenetic protein type 2 receptor mutations disease severity endothelial nitric oxide synthase experimental pulmonary hypertension hereditary pulmonary arterial hypertension Hypotheses Hypoxia Mutation non‐sense‐mediated messenger RNA decay Original Research Proteins Pulmonary hypertension
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!