CRISPR-Cas : revolutionising genome engineering : in practice - clinical update
The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future. This ar...
Gespeichert in:
| Veröffentlicht in: | South African medical journal 2016-09, Vol.106 (9), p.870-871 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 871 |
|---|---|
| container_issue | 9 |
| container_start_page | 870 |
| container_title | South African medical journal |
| container_volume | 106 |
| creator | Pepper, M.S. Nicholson, S.A. Pepper, M.S. Nicholson, S.A. |
| description | The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future. This article discusses recent advancements in the technology called 'clustered regularly interspaced palindromic repeat (CRISPR)-associated genes' (CRISPR-Cas), the potential of CRISPR-Cas to revolutionise molecular medicine, and the ethical and regulatory hurdles facing its application. |
| doi_str_mv | 10.7196/SAMJ.2016.v106i9.11061 |
| format | Article |
| fullrecord | <record><control><sourceid>sabinet_JRA</sourceid><recordid>TN_cdi_sabinet_saepub_10520_EJC195659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sabinet_id>10520/EJC195659</sabinet_id><sourcerecordid>10520/EJC195659</sourcerecordid><originalsourceid>FETCH-sabinet_saepub_10520_EJC1956593</originalsourceid><addsrcrecordid>eNqNjMFqwkAURYdSoVH7C_I2XU46LzqTjrsSLDYgiroPY_oMr6STkEn8_qbgB3R1uIfLEWKBKk7RmtfT-y6PE4UmvqEybGMcgQ8iSlT6JjUu9aOIVKKNtDpdPYlpCN9q3NqaSOyz4-fpcJSZC7CGjm5NPfTceA7sK6jINz8E5Cv2RN2fWgN7aDtX9lwSSChr9ly6Gob2y_U0F5OrqwM93zkTLx-bc7aVwV3GRl8ER-1wKVDpRBWbPEOrjbbL__5-AXeFRVY</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>CRISPR-Cas : revolutionising genome engineering : in practice - clinical update</title><source>Sabinet African Journals Open Access Collection</source><creator>Pepper, M.S. ; Nicholson, S.A. ; Pepper, M.S. ; Nicholson, S.A.</creator><creatorcontrib>Pepper, M.S. ; Nicholson, S.A. ; Pepper, M.S. ; Nicholson, S.A.</creatorcontrib><description>The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future. This article discusses recent advancements in the technology called 'clustered regularly interspaced palindromic repeat (CRISPR)-associated genes' (CRISPR-Cas), the potential of CRISPR-Cas to revolutionise molecular medicine, and the ethical and regulatory hurdles facing its application.</description><identifier>ISSN: 0256-9574</identifier><identifier>EISSN: 2078-5135</identifier><identifier>DOI: 10.7196/SAMJ.2016.v106i9.11061</identifier><language>eng</language><publisher>Health and Medical Publishing Group (HMPG)</publisher><ispartof>South African medical journal, 2016-09, Vol.106 (9), p.870-871</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27929,27930,39247</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/10520/EJC195659$$EView_record_in_Sabinet_Online_Ltd.$$FView_record_in_$$GSabinet_Online_Ltd.</linktorsrc></links><search><creatorcontrib>Pepper, M.S.</creatorcontrib><creatorcontrib>Nicholson, S.A.</creatorcontrib><creatorcontrib>Pepper, M.S.</creatorcontrib><creatorcontrib>Nicholson, S.A.</creatorcontrib><title>CRISPR-Cas : revolutionising genome engineering : in practice - clinical update</title><title>South African medical journal</title><description>The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future. This article discusses recent advancements in the technology called 'clustered regularly interspaced palindromic repeat (CRISPR)-associated genes' (CRISPR-Cas), the potential of CRISPR-Cas to revolutionise molecular medicine, and the ethical and regulatory hurdles facing its application.</description><issn>0256-9574</issn><issn>2078-5135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqNjMFqwkAURYdSoVH7C_I2XU46LzqTjrsSLDYgiroPY_oMr6STkEn8_qbgB3R1uIfLEWKBKk7RmtfT-y6PE4UmvqEybGMcgQ8iSlT6JjUu9aOIVKKNtDpdPYlpCN9q3NqaSOyz4-fpcJSZC7CGjm5NPfTceA7sK6jINz8E5Cv2RN2fWgN7aDtX9lwSSChr9ly6Gob2y_U0F5OrqwM93zkTLx-bc7aVwV3GRl8ER-1wKVDpRBWbPEOrjbbL__5-AXeFRVY</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Pepper, M.S.</creator><creator>Nicholson, S.A.</creator><creator>Pepper, M.S.</creator><creator>Nicholson, S.A.</creator><general>Health and Medical Publishing Group (HMPG)</general><scope/></search><sort><creationdate>20160901</creationdate><title>CRISPR-Cas : revolutionising genome engineering : in practice - clinical update</title><author>Pepper, M.S. ; Nicholson, S.A. ; Pepper, M.S. ; Nicholson, S.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-sabinet_saepub_10520_EJC1956593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pepper, M.S.</creatorcontrib><creatorcontrib>Nicholson, S.A.</creatorcontrib><creatorcontrib>Pepper, M.S.</creatorcontrib><creatorcontrib>Nicholson, S.A.</creatorcontrib><jtitle>South African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Pepper, M.S.</au><au>Nicholson, S.A.</au><au>Pepper, M.S.</au><au>Nicholson, S.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CRISPR-Cas : revolutionising genome engineering : in practice - clinical update</atitle><jtitle>South African medical journal</jtitle><date>2016-09-01</date><risdate>2016</risdate><volume>106</volume><issue>9</issue><spage>870</spage><epage>871</epage><pages>870-871</pages><issn>0256-9574</issn><eissn>2078-5135</eissn><abstract>The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future. This article discusses recent advancements in the technology called 'clustered regularly interspaced palindromic repeat (CRISPR)-associated genes' (CRISPR-Cas), the potential of CRISPR-Cas to revolutionise molecular medicine, and the ethical and regulatory hurdles facing its application.</abstract><pub>Health and Medical Publishing Group (HMPG)</pub><doi>10.7196/SAMJ.2016.v106i9.11061</doi></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0256-9574 |
| ispartof | South African medical journal, 2016-09, Vol.106 (9), p.870-871 |
| issn | 0256-9574 2078-5135 |
| language | eng |
| recordid | cdi_sabinet_saepub_10520_EJC195659 |
| source | Sabinet African Journals Open Access Collection |
| title | CRISPR-Cas : revolutionising genome engineering : in practice - clinical update |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T04%3A56%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sabinet_JRA&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CRISPR-Cas%20:%20revolutionising%20genome%20engineering%20:%20in%20practice%20-%20clinical%20update&rft.jtitle=South%20African%20medical%20journal&rft.au=Pepper,%20M.S.&rft.date=2016-09-01&rft.volume=106&rft.issue=9&rft.spage=870&rft.epage=871&rft.pages=870-871&rft.issn=0256-9574&rft.eissn=2078-5135&rft_id=info:doi/10.7196/SAMJ.2016.v106i9.11061&rft_dat=%3Csabinet_JRA%3E10520/EJC195659%3C/sabinet_JRA%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_sabinet_id=10520/EJC195659&rfr_iscdi=true |