Metal-free approach for imidazole synthesis one-pot -α-C(sp)- bond functionalization of benzylamines
A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles from the reaction of arylmethylamines and 1,2-dicarbonyls/benzoin. The N -α-C(sp 3 )- H bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under ae...
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| Veröffentlicht in: | RSC advances 2024-09, Vol.14 (39), p.28332-28339 |
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| container_end_page | 28339 |
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| container_issue | 39 |
| container_start_page | 28332 |
| container_title | RSC advances |
| container_volume | 14 |
| creator | Kadu, Vikas D Thokal, Machhindra S Godase, Rajkumar K Kotali, Bhagyashree C Wadkar, Pooja S |
| description | A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles from the reaction of arylmethylamines and 1,2-dicarbonyls/benzoin. The
N
-α-C(sp
3
)-
H
bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under aerobic conditions in significant yields of up to 95%.
A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles from the reaction of arylmethylamines and 1,2-dicarbonyls/benzoin. |
| doi_str_mv | 10.1039/d4ra03939d |
| format | Article |
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N
-α-C(sp
3
)-
H
bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under aerobic conditions in significant yields of up to 95%.
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N
-α-C(sp
3
)-
H
bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under aerobic conditions in significant yields of up to 95%.
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N
-α-C(sp
3
)-
H
bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under aerobic conditions in significant yields of up to 95%.
A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles from the reaction of arylmethylamines and 1,2-dicarbonyls/benzoin.</abstract><doi>10.1039/d4ra03939d</doi><tpages>8</tpages></addata></record> |
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| ispartof | RSC advances, 2024-09, Vol.14 (39), p.28332-28339 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| title | Metal-free approach for imidazole synthesis one-pot -α-C(sp)- bond functionalization of benzylamines |
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