Synthesis of novel phthalazine-based derivatives with potent cytotoxicity against HCT-116 cells through apoptosis and VEGFR2 inhibition

The parent ethyl 3-(4-benzyl-1-oxophthalazin-2(1 H )-yl) propanoate ( 3 ) has 25 compounds. Their respective mono, dipeptides and hydrazones derivatives were produced by chemoselective N -alkylation via addition reaction of 4-benzylphthalazin-1(2 H )-one ( 2 ) with ethyl acrylate and anhydrous potas...

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Veröffentlicht in:	RSC advances 2024-04, Vol.14 (19), p.1327-1343
Hauptverfasser:	El Sayed, Donia, El Rayes, Samir M, Soliman, Hamdy A, AlBalaa, Imad Eddin, Alturki, Mansour S, Al Khzem, Abdulaziz Hassan, Alsharif, Mohammed Abdullah, Nafie, Mohamed S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Alkylation Amines Amino acids Apoptosis Chemistry Cytotoxicity Esters Hydrazides Hydrazones Potassium carbonate Toxicity
Online-Zugang:	Volltext
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