Synthesis of α-ketoamides oxidative amidation of diazo compounds with -benzoyl hydroxylamines as nitrogen source and the oxidant
A simple, efficient method has been described for the construction of an array of α-ketoamides from readily available O -benzoyl hydroxylamines and diazo compounds as starting materials. There was a combined use of CuI as a catalyst and H 2 O as the oxygen source. The investigation reveals that the...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2024-08, Vol.22 (33), p.678-6712 |
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| container_issue | 33 |
| container_start_page | 678 |
| container_title | Organic & biomolecular chemistry |
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| creator | Chen, Wenwen Zhang, Xinyin Wang, Xinyu Zhang, EnXuan Wang, Zu-Li Jia, Jianfeng |
| description | A simple, efficient method has been described for the construction of an array of α-ketoamides from readily available
O
-benzoyl hydroxylamines and diazo compounds as starting materials. There was a combined use of CuI as a catalyst and H
2
O as the oxygen source. The investigation reveals that the
O
-benzoyl hydroxylamines serve a dual role as both an amine source and the oxidant in this mechanism, thereby obviating the need for additional oxidants in the transformation process. This methodology could give a wider range of products in good to excellent yields for most substrates, and thus, we provide a new idea for the synthesis of α-ketoamides.
An efficient method for the construction of an array of α-ketoamides has been described from readily available
O
-benzoyl hydroxylamines and diazo compounds as starting materials by the combined use of CuI as a catalyst and H
2
O as oxygen source. |
| doi_str_mv | 10.1039/d4ob00883a |
| format | Article |
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O
-benzoyl hydroxylamines and diazo compounds as starting materials. There was a combined use of CuI as a catalyst and H
2
O as the oxygen source. The investigation reveals that the
O
-benzoyl hydroxylamines serve a dual role as both an amine source and the oxidant in this mechanism, thereby obviating the need for additional oxidants in the transformation process. This methodology could give a wider range of products in good to excellent yields for most substrates, and thus, we provide a new idea for the synthesis of α-ketoamides.
An efficient method for the construction of an array of α-ketoamides has been described from readily available
O
-benzoyl hydroxylamines and diazo compounds as starting materials by the combined use of CuI as a catalyst and H
2
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O
-benzoyl hydroxylamines and diazo compounds as starting materials. There was a combined use of CuI as a catalyst and H
2
O as the oxygen source. The investigation reveals that the
O
-benzoyl hydroxylamines serve a dual role as both an amine source and the oxidant in this mechanism, thereby obviating the need for additional oxidants in the transformation process. This methodology could give a wider range of products in good to excellent yields for most substrates, and thus, we provide a new idea for the synthesis of α-ketoamides.
An efficient method for the construction of an array of α-ketoamides has been described from readily available
O
-benzoyl hydroxylamines and diazo compounds as starting materials by the combined use of CuI as a catalyst and H
2
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O
-benzoyl hydroxylamines and diazo compounds as starting materials. There was a combined use of CuI as a catalyst and H
2
O as the oxygen source. The investigation reveals that the
O
-benzoyl hydroxylamines serve a dual role as both an amine source and the oxidant in this mechanism, thereby obviating the need for additional oxidants in the transformation process. This methodology could give a wider range of products in good to excellent yields for most substrates, and thus, we provide a new idea for the synthesis of α-ketoamides.
An efficient method for the construction of an array of α-ketoamides has been described from readily available
O
-benzoyl hydroxylamines and diazo compounds as starting materials by the combined use of CuI as a catalyst and H
2
O as oxygen source.</abstract><doi>10.1039/d4ob00883a</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2024-08, Vol.22 (33), p.678-6712 |
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| recordid | cdi_rsc_primary_d4ob00883a |
| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| title | Synthesis of α-ketoamides oxidative amidation of diazo compounds with -benzoyl hydroxylamines as nitrogen source and the oxidant |
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