Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5-pyrrolo[1,2-][1,2,4]triazole derivatives as necroptosis inhibitors

The development of necroptosis inhibitors has emerged as a promising strategy to effectively mitigate necroptosis-related inflammatory diseases, neurodegenerative diseases, and cancers. In this paper, we reported a series of 6,7-dihydro-5 H -pyrrolo[1,2- b ][1,2,4]triazole derivatives as potent necr...

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Veröffentlicht in:	RSC medicinal chemistry 2024-07, Vol.15 (7), p.2514-2526
Hauptverfasser:	Jin, Zechen, Dai, Yang, Ji, Yinchun, Peng, Xia, Duan, Wenhu, Ai, Jing, Zhang, Hefeng
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