Enhanced selectivity towards melanoma cells with zinc()-Schiff bases containing imidazole derivatives
Zinc( ii )-complexes with the general formula [Zn(L) 2 ] containing 8-hydroxyquinoline Schiff bases functionalized with 1-(3-aminopropyl)imidazole or 1-(3-aminopropyl)-2-methyl-1 H -imidazole on 2-position and their respective ligands ( HL 1 or HL 2 ) were synthesized and characterized by NMR, UV-Vi...
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2024-06, Vol.53 (22), p.9416-9432 |
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| creator | Côrte-Real, Leonor Sergi, Baris Yildirim, Busra Colucas, Raquel Starosta, Rados aw Fontrodona, Xavier Romero, Isabel André, Vânia Acilan, Ceyda Correia, Isabel |
| description | Zinc(
ii
)-complexes with the general formula [Zn(L)
2
] containing 8-hydroxyquinoline Schiff bases functionalized with 1-(3-aminopropyl)imidazole or 1-(3-aminopropyl)-2-methyl-1
H
-imidazole on 2-position and their respective ligands (
HL
1
or
HL
2
) were synthesized and characterized by NMR, UV-Vis, FTIR and CD spectroscopies as well as ESI-MS spectrometry. Single crystals of
HL
2
and
[Zn(L
1
)
2
]
n
were analysed by SC-XRD.
[Zn(L
1
)
2
]
n
shows a 1D polymeric chain structure of alternating Zn(
ii
) cations and bridging Schiff base ligands, in contrast to previously reported monomeric structures of analogous complexes. DFT calculations were performed to rationalize the polymeric X-ray structure of
Zn(L
1
)
2
. Results showed that the ligands can bind as bi- or tridentate to Zn(
ii
) and there is the possibility of a dynamic behavior for the complexes in solution. Both ligands and complexes present limited stability in aqueous media, however, in the presence of bovine serum albumin the complexes are stable. Molecular docking simulations and circular dichroism spectroscopic studies suggest binding to this protein in close proximity to the Trp213 residue. Biological studies on a panel of cancer cells revealed that the Zn(
ii
)-complexes have a lower impact on cell viability than cisplatin, except for triple-negative breast cancer cells in which they were comparable. Notwithstanding, they display much higher selectivity towards cancer cells
vs.
normal cells, than cisplatin. They induce the generation of ROS and DNA double-strand breaks, primarily through apoptosis as the mode of cell death. Overall, the novel Zn(
ii
)-complexes demonstrate improved induction of apoptosis and higher selectivity, particularly for melanoma cells, compared to previously reported analogues, making them promising candidates for clinical application.
New Schiff base Zn(
ii
)-complexes of 8-hydroxyquinoline and imidazole display much higher selectivity towards cancer cells than cisplatin. |
| doi_str_mv | 10.1039/d4dt00733f |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_rsc_p</sourceid><recordid>TN_cdi_rsc_primary_d4dt00733f</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3064042717</sourcerecordid><originalsourceid>FETCH-LOGICAL-c226t-8c4d98c2e799bbcc9a320b5acaf7fe9feade829d406597f138d91fab63a734073</originalsourceid><addsrcrecordid>eNpdkU1r3DAQhkVpyKabXHpvEfSSBpzI-rCsY8hHEwj00M3ZjKVRV8GWU8mbkPz6ervbDeQ0A_Pw8vIMIZ9LdloyYc6cdCNjWgj_gRyUUuvCcCE_7nZezcinnB8Y45wpvk9motaqZlwdELyKS4gWHc3YoR3DUxhf6Dg8Q3KZ9thBHHqgFrsu0-cwLulriPb4e_HLLoP3tIWMmdohjhBiiL9p6IOD16FD6jCFJ5gSMR-SPQ9dxqPtnJP766vFxU1x9_PH7cX5XWGnkmNRW-lMbTlqY9rWWgOCs1aBBa89Go_gsObGSVYpo30pamdKD20lQAs5GZiT403uYxr-rDCPTR_yujtEHFa5EUxVVaWUkhP67R36MKxSnNpNVCWZ5LpcB55sKJuGnBP65jGFHtJLU7JmLb-5lJeLf_KvJ_jrNnLV9uh26H_bE_BlA6Rsd9e374m_BpaKVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3064042717</pqid></control><display><type>article</type><title>Enhanced selectivity towards melanoma cells with zinc()-Schiff bases containing imidazole derivatives</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Côrte-Real, Leonor ; Sergi, Baris ; Yildirim, Busra ; Colucas, Raquel ; Starosta, Rados aw ; Fontrodona, Xavier ; Romero, Isabel ; André, Vânia ; Acilan, Ceyda ; Correia, Isabel</creator><creatorcontrib>Côrte-Real, Leonor ; Sergi, Baris ; Yildirim, Busra ; Colucas, Raquel ; Starosta, Rados aw ; Fontrodona, Xavier ; Romero, Isabel ; André, Vânia ; Acilan, Ceyda ; Correia, Isabel</creatorcontrib><description>Zinc(
ii
)-complexes with the general formula [Zn(L)
2
] containing 8-hydroxyquinoline Schiff bases functionalized with 1-(3-aminopropyl)imidazole or 1-(3-aminopropyl)-2-methyl-1
H
-imidazole on 2-position and their respective ligands (
HL
1
or
HL
2
) were synthesized and characterized by NMR, UV-Vis, FTIR and CD spectroscopies as well as ESI-MS spectrometry. Single crystals of
HL
2
and
[Zn(L
1
)
2
]
n
were analysed by SC-XRD.
[Zn(L
1
)
2
]
n
shows a 1D polymeric chain structure of alternating Zn(
ii
) cations and bridging Schiff base ligands, in contrast to previously reported monomeric structures of analogous complexes. DFT calculations were performed to rationalize the polymeric X-ray structure of
Zn(L
1
)
2
. Results showed that the ligands can bind as bi- or tridentate to Zn(
ii
) and there is the possibility of a dynamic behavior for the complexes in solution. Both ligands and complexes present limited stability in aqueous media, however, in the presence of bovine serum albumin the complexes are stable. Molecular docking simulations and circular dichroism spectroscopic studies suggest binding to this protein in close proximity to the Trp213 residue. Biological studies on a panel of cancer cells revealed that the Zn(
ii
)-complexes have a lower impact on cell viability than cisplatin, except for triple-negative breast cancer cells in which they were comparable. Notwithstanding, they display much higher selectivity towards cancer cells
vs.
normal cells, than cisplatin. They induce the generation of ROS and DNA double-strand breaks, primarily through apoptosis as the mode of cell death. Overall, the novel Zn(
ii
)-complexes demonstrate improved induction of apoptosis and higher selectivity, particularly for melanoma cells, compared to previously reported analogues, making them promising candidates for clinical application.
New Schiff base Zn(
ii
)-complexes of 8-hydroxyquinoline and imidazole display much higher selectivity towards cancer cells than cisplatin.</description><identifier>ISSN: 1477-9226</identifier><identifier>EISSN: 1477-9234</identifier><identifier>DOI: 10.1039/d4dt00733f</identifier><identifier>PMID: 38758025</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Aqueous solutions ; Cancer ; Cell death ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Coordination Complexes - chemical synthesis ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Density Functional Theory ; Dichroism ; Drug Screening Assays, Antitumor ; Humans ; Hydroxyquinoline ; Imidazole ; Imidazoles - chemistry ; Imidazoles - pharmacology ; Imines ; Ligands ; Melanoma ; Melanoma - drug therapy ; Melanoma - pathology ; Molecular docking ; Molecular Docking Simulation ; Molecular Structure ; NMR ; Nuclear magnetic resonance ; Schiff Bases - chemistry ; Schiff Bases - pharmacology ; Serum albumin ; Serum Albumin, Bovine - chemistry ; Single crystals ; Zinc - chemistry ; Zinc - pharmacology ; Zinc compounds</subject><ispartof>Dalton transactions : an international journal of inorganic chemistry, 2024-06, Vol.53 (22), p.9416-9432</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c226t-8c4d98c2e799bbcc9a320b5acaf7fe9feade829d406597f138d91fab63a734073</cites><orcidid>0000-0001-7096-4284 ; 0000-0002-8936-3267 ; 0000-0003-4805-8394 ; 0000-0002-6379-2362 ; 0000-0002-4974-1075 ; 0000-0001-6557-541X ; 0000-0001-5599-8355 ; 0009-0002-8188-9384</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38758025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Côrte-Real, Leonor</creatorcontrib><creatorcontrib>Sergi, Baris</creatorcontrib><creatorcontrib>Yildirim, Busra</creatorcontrib><creatorcontrib>Colucas, Raquel</creatorcontrib><creatorcontrib>Starosta, Rados aw</creatorcontrib><creatorcontrib>Fontrodona, Xavier</creatorcontrib><creatorcontrib>Romero, Isabel</creatorcontrib><creatorcontrib>André, Vânia</creatorcontrib><creatorcontrib>Acilan, Ceyda</creatorcontrib><creatorcontrib>Correia, Isabel</creatorcontrib><title>Enhanced selectivity towards melanoma cells with zinc()-Schiff bases containing imidazole derivatives</title><title>Dalton transactions : an international journal of inorganic chemistry</title><addtitle>Dalton Trans</addtitle><description>Zinc(
ii
)-complexes with the general formula [Zn(L)
2
] containing 8-hydroxyquinoline Schiff bases functionalized with 1-(3-aminopropyl)imidazole or 1-(3-aminopropyl)-2-methyl-1
H
-imidazole on 2-position and their respective ligands (
HL
1
or
HL
2
) were synthesized and characterized by NMR, UV-Vis, FTIR and CD spectroscopies as well as ESI-MS spectrometry. Single crystals of
HL
2
and
[Zn(L
1
)
2
]
n
were analysed by SC-XRD.
[Zn(L
1
)
2
]
n
shows a 1D polymeric chain structure of alternating Zn(
ii
) cations and bridging Schiff base ligands, in contrast to previously reported monomeric structures of analogous complexes. DFT calculations were performed to rationalize the polymeric X-ray structure of
Zn(L
1
)
2
. Results showed that the ligands can bind as bi- or tridentate to Zn(
ii
) and there is the possibility of a dynamic behavior for the complexes in solution. Both ligands and complexes present limited stability in aqueous media, however, in the presence of bovine serum albumin the complexes are stable. Molecular docking simulations and circular dichroism spectroscopic studies suggest binding to this protein in close proximity to the Trp213 residue. Biological studies on a panel of cancer cells revealed that the Zn(
ii
)-complexes have a lower impact on cell viability than cisplatin, except for triple-negative breast cancer cells in which they were comparable. Notwithstanding, they display much higher selectivity towards cancer cells
vs.
normal cells, than cisplatin. They induce the generation of ROS and DNA double-strand breaks, primarily through apoptosis as the mode of cell death. Overall, the novel Zn(
ii
)-complexes demonstrate improved induction of apoptosis and higher selectivity, particularly for melanoma cells, compared to previously reported analogues, making them promising candidates for clinical application.
New Schiff base Zn(
ii
)-complexes of 8-hydroxyquinoline and imidazole display much higher selectivity towards cancer cells than cisplatin.</description><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Aqueous solutions</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Coordination Complexes - chemical synthesis</subject><subject>Coordination Complexes - chemistry</subject><subject>Coordination Complexes - pharmacology</subject><subject>Density Functional Theory</subject><subject>Dichroism</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Humans</subject><subject>Hydroxyquinoline</subject><subject>Imidazole</subject><subject>Imidazoles - chemistry</subject><subject>Imidazoles - pharmacology</subject><subject>Imines</subject><subject>Ligands</subject><subject>Melanoma</subject><subject>Melanoma - drug therapy</subject><subject>Melanoma - pathology</subject><subject>Molecular docking</subject><subject>Molecular Docking Simulation</subject><subject>Molecular Structure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Schiff Bases - chemistry</subject><subject>Schiff Bases - pharmacology</subject><subject>Serum albumin</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>Single crystals</subject><subject>Zinc - chemistry</subject><subject>Zinc - pharmacology</subject><subject>Zinc compounds</subject><issn>1477-9226</issn><issn>1477-9234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1r3DAQhkVpyKabXHpvEfSSBpzI-rCsY8hHEwj00M3ZjKVRV8GWU8mbkPz6ervbDeQ0A_Pw8vIMIZ9LdloyYc6cdCNjWgj_gRyUUuvCcCE_7nZezcinnB8Y45wpvk9motaqZlwdELyKS4gWHc3YoR3DUxhf6Dg8Q3KZ9thBHHqgFrsu0-cwLulriPb4e_HLLoP3tIWMmdohjhBiiL9p6IOD16FD6jCFJ5gSMR-SPQ9dxqPtnJP766vFxU1x9_PH7cX5XWGnkmNRW-lMbTlqY9rWWgOCs1aBBa89Go_gsObGSVYpo30pamdKD20lQAs5GZiT403uYxr-rDCPTR_yujtEHFa5EUxVVaWUkhP67R36MKxSnNpNVCWZ5LpcB55sKJuGnBP65jGFHtJLU7JmLb-5lJeLf_KvJ_jrNnLV9uh26H_bE_BlA6Rsd9e374m_BpaKVg</recordid><startdate>20240604</startdate><enddate>20240604</enddate><creator>Côrte-Real, Leonor</creator><creator>Sergi, Baris</creator><creator>Yildirim, Busra</creator><creator>Colucas, Raquel</creator><creator>Starosta, Rados aw</creator><creator>Fontrodona, Xavier</creator><creator>Romero, Isabel</creator><creator>André, Vânia</creator><creator>Acilan, Ceyda</creator><creator>Correia, Isabel</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7096-4284</orcidid><orcidid>https://orcid.org/0000-0002-8936-3267</orcidid><orcidid>https://orcid.org/0000-0003-4805-8394</orcidid><orcidid>https://orcid.org/0000-0002-6379-2362</orcidid><orcidid>https://orcid.org/0000-0002-4974-1075</orcidid><orcidid>https://orcid.org/0000-0001-6557-541X</orcidid><orcidid>https://orcid.org/0000-0001-5599-8355</orcidid><orcidid>https://orcid.org/0009-0002-8188-9384</orcidid></search><sort><creationdate>20240604</creationdate><title>Enhanced selectivity towards melanoma cells with zinc()-Schiff bases containing imidazole derivatives</title><author>Côrte-Real, Leonor ; Sergi, Baris ; Yildirim, Busra ; Colucas, Raquel ; Starosta, Rados aw ; Fontrodona, Xavier ; Romero, Isabel ; André, Vânia ; Acilan, Ceyda ; Correia, Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-8c4d98c2e799bbcc9a320b5acaf7fe9feade829d406597f138d91fab63a734073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Aqueous solutions</topic><topic>Cancer</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Coordination Complexes - chemical synthesis</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination Complexes - pharmacology</topic><topic>Density Functional Theory</topic><topic>Dichroism</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Humans</topic><topic>Hydroxyquinoline</topic><topic>Imidazole</topic><topic>Imidazoles - chemistry</topic><topic>Imidazoles - pharmacology</topic><topic>Imines</topic><topic>Ligands</topic><topic>Melanoma</topic><topic>Melanoma - drug therapy</topic><topic>Melanoma - pathology</topic><topic>Molecular docking</topic><topic>Molecular Docking Simulation</topic><topic>Molecular Structure</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Schiff Bases - chemistry</topic><topic>Schiff Bases - pharmacology</topic><topic>Serum albumin</topic><topic>Serum Albumin, Bovine - chemistry</topic><topic>Single crystals</topic><topic>Zinc - chemistry</topic><topic>Zinc - pharmacology</topic><topic>Zinc compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Côrte-Real, Leonor</creatorcontrib><creatorcontrib>Sergi, Baris</creatorcontrib><creatorcontrib>Yildirim, Busra</creatorcontrib><creatorcontrib>Colucas, Raquel</creatorcontrib><creatorcontrib>Starosta, Rados aw</creatorcontrib><creatorcontrib>Fontrodona, Xavier</creatorcontrib><creatorcontrib>Romero, Isabel</creatorcontrib><creatorcontrib>André, Vânia</creatorcontrib><creatorcontrib>Acilan, Ceyda</creatorcontrib><creatorcontrib>Correia, Isabel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Côrte-Real, Leonor</au><au>Sergi, Baris</au><au>Yildirim, Busra</au><au>Colucas, Raquel</au><au>Starosta, Rados aw</au><au>Fontrodona, Xavier</au><au>Romero, Isabel</au><au>André, Vânia</au><au>Acilan, Ceyda</au><au>Correia, Isabel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced selectivity towards melanoma cells with zinc()-Schiff bases containing imidazole derivatives</atitle><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle><addtitle>Dalton Trans</addtitle><date>2024-06-04</date><risdate>2024</risdate><volume>53</volume><issue>22</issue><spage>9416</spage><epage>9432</epage><pages>9416-9432</pages><issn>1477-9226</issn><eissn>1477-9234</eissn><abstract>Zinc(
ii
)-complexes with the general formula [Zn(L)
2
] containing 8-hydroxyquinoline Schiff bases functionalized with 1-(3-aminopropyl)imidazole or 1-(3-aminopropyl)-2-methyl-1
H
-imidazole on 2-position and their respective ligands (
HL
1
or
HL
2
) were synthesized and characterized by NMR, UV-Vis, FTIR and CD spectroscopies as well as ESI-MS spectrometry. Single crystals of
HL
2
and
[Zn(L
1
)
2
]
n
were analysed by SC-XRD.
[Zn(L
1
)
2
]
n
shows a 1D polymeric chain structure of alternating Zn(
ii
) cations and bridging Schiff base ligands, in contrast to previously reported monomeric structures of analogous complexes. DFT calculations were performed to rationalize the polymeric X-ray structure of
Zn(L
1
)
2
. Results showed that the ligands can bind as bi- or tridentate to Zn(
ii
) and there is the possibility of a dynamic behavior for the complexes in solution. Both ligands and complexes present limited stability in aqueous media, however, in the presence of bovine serum albumin the complexes are stable. Molecular docking simulations and circular dichroism spectroscopic studies suggest binding to this protein in close proximity to the Trp213 residue. Biological studies on a panel of cancer cells revealed that the Zn(
ii
)-complexes have a lower impact on cell viability than cisplatin, except for triple-negative breast cancer cells in which they were comparable. Notwithstanding, they display much higher selectivity towards cancer cells
vs.
normal cells, than cisplatin. They induce the generation of ROS and DNA double-strand breaks, primarily through apoptosis as the mode of cell death. Overall, the novel Zn(
ii
)-complexes demonstrate improved induction of apoptosis and higher selectivity, particularly for melanoma cells, compared to previously reported analogues, making them promising candidates for clinical application.
New Schiff base Zn(
ii
)-complexes of 8-hydroxyquinoline and imidazole display much higher selectivity towards cancer cells than cisplatin.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38758025</pmid><doi>10.1039/d4dt00733f</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-7096-4284</orcidid><orcidid>https://orcid.org/0000-0002-8936-3267</orcidid><orcidid>https://orcid.org/0000-0003-4805-8394</orcidid><orcidid>https://orcid.org/0000-0002-6379-2362</orcidid><orcidid>https://orcid.org/0000-0002-4974-1075</orcidid><orcidid>https://orcid.org/0000-0001-6557-541X</orcidid><orcidid>https://orcid.org/0000-0001-5599-8355</orcidid><orcidid>https://orcid.org/0009-0002-8188-9384</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2024-06, Vol.53 (22), p.9416-9432 |
| issn | 1477-9226 1477-9234 |
| language | eng |
| recordid | cdi_rsc_primary_d4dt00733f |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Aqueous solutions Cancer Cell death Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Density Functional Theory Dichroism Drug Screening Assays, Antitumor Humans Hydroxyquinoline Imidazole Imidazoles - chemistry Imidazoles - pharmacology Imines Ligands Melanoma Melanoma - drug therapy Melanoma - pathology Molecular docking Molecular Docking Simulation Molecular Structure NMR Nuclear magnetic resonance Schiff Bases - chemistry Schiff Bases - pharmacology Serum albumin Serum Albumin, Bovine - chemistry Single crystals Zinc - chemistry Zinc - pharmacology Zinc compounds |
| title | Enhanced selectivity towards melanoma cells with zinc()-Schiff bases containing imidazole derivatives |
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