Brønsted acid-mediated thiazole synthesis from sulfoxonium ylides
A Brønsted acid-mediated insertion of thioureas/thioamides into sulfoxonium ylides to synthesise 40 thiazoles (34-95% yields) under mild, metal-free conditions is described. This process is scalable, substrate-tolerant (including both α-substituted and heterocyclic ylides/groups) and was successfull...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2024-10, Vol.6 (85), p.1241-1244 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Smy, Joe L Ifill, Roxanne Hassell-Hart, Storm |
| description | A Brønsted acid-mediated insertion of thioureas/thioamides into sulfoxonium ylides to synthesise 40 thiazoles (34-95% yields) under mild, metal-free conditions is described. This process is scalable, substrate-tolerant (including both α-substituted and heterocyclic ylides/groups) and was successfully applied to the late-stage functionalisation of the complex chemical probe molecule (+)-JQ1.
A Brønsted acid-mediated insertion of thioureas/thioamides into sulfoxonium ylides to synthesise 40 thiazoles (34-95% yields) under mild, metal-free conditions is described. |
| doi_str_mv | 10.1039/d4cc03905j |
| format | Article |
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| ispartof | Chemical communications (Cambridge, England), 2024-10, Vol.6 (85), p.1241-1244 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Brønsted acid-mediated thiazole synthesis from sulfoxonium ylides |
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