Divergent synthesis of δ-valerolactones and furanones palladium or copper-catalyzed α-hydroxycyclopropanol ring opening cyclizations
Cyclopropanols are versatile starting materials which can undergo various ring opening reactions due to their intrisic ring strain. Herein, we report two transition metal-catalyzed α-hydroxycyclopropanol ring opening cyclizations to divergently transform the same α-hydroxycyclopropanol substrate int...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2024-09, Vol.6 (74), p.1112-1115 |
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| creator | de Andrade Horn, Pedro Collins, Michael J. E Gudeman, Cyrus C Fresh, Alexandra A Dai, Mingji |
| description | Cyclopropanols are versatile starting materials which can undergo various ring opening reactions due to their intrisic ring strain. Herein, we report two transition metal-catalyzed α-hydroxycyclopropanol ring opening cyclizations to divergently transform the same α-hydroxycyclopropanol substrate into two different products of enhanced value. One is a palladium-catalyzed α-hydroxycyclopropanol ring opening carbonylative lactonization to synthesize δ-valerolactones. The other one is a copper-catalyzed α-hydroxycyclopropanol ring opening cyclization to access furanones.
Divergent approaches were developed to synthesize δ-valerolactones or furanones
via
a palladium or copper-catalyzed α-hydroxycyclopropanol ring opening cyclizations, respectively. |
| doi_str_mv | 10.1039/d4cc03255a |
| format | Article |
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Divergent approaches were developed to synthesize δ-valerolactones or furanones
via
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Divergent approaches were developed to synthesize δ-valerolactones or furanones
via
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Divergent approaches were developed to synthesize δ-valerolactones or furanones
via
a palladium or copper-catalyzed α-hydroxycyclopropanol ring opening cyclizations, respectively.</abstract><doi>10.1039/d4cc03255a</doi><tpages>4</tpages></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Divergent synthesis of δ-valerolactones and furanones palladium or copper-catalyzed α-hydroxycyclopropanol ring opening cyclizations |
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