Pd-catalyzed Suzuki-type cross-coupling of 2-pyridyl carbamoyl fluorides

We describe a palladium-catalyzed Suzuki-type cross-coupling reaction of 2-pyridyl carbamoyl fluorides with boronic acids, which provides entry to medicinally relevant pyridyl amides. Mechanistic studies, including the synthesis and reactivity of carbamoyl Pd-F complexes, reveal the importance of bo...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2024-08, Vol.6 (66), p.87-873
Hauptverfasser:	Jabbarpoor, Maryam, LeBlanc, Jesse, Chen, Zichuan, Cadwallader, Dusty, Le, Christine M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Chemical reactions Cross coupling Fluorides Palladium
Online-Zugang:	Volltext
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