Enzyme-loaded rod-like microgel shapes: a step towards the creation of shape-specific microreactors for blood detoxification purposes

Rapid removal of toxic substances is crucial to restore the normal functions of our body and ensure survival. Due to their high substrate specificity and catalytic efficiency, enzymes are unique candidates to deplete toxic compounds. While enzymes display several limitations including low stability...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-05, Vol.12 (19), p.4736-4747
Hauptverfasser:	Bishnoi, Shahana, Jansman, Michelle Maria Theresia, Chen, Jiantao, Thulstrup, Peter Waaben, Keller, Stephan Sylvest, Hosta-Rigau, Leticia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - metabolism Biocompatible Materials - pharmacology Blood Cell Survival - drug effects Cell viability Denaturation Depletion Detoxification Endothelial cells Enzymes Fabrication Hemolysis Humans Immunogenicity Macrophages Mice Microgels Microgels - chemistry Microreactors Particle Size Residence time Shape Substrate specificity Substrates Surface Properties Toxic substances β Lactamase
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