A novel fluoropolymer as a protein delivery vector with robust adjuvant effect for cancer immunotherapy

The inefficient treatment using protein-based nanovaccines is largely attributed to their inadequate immunogenicity. Herein, we developed a novel fluoropolymer (PF) via ring-opening polymerization and constructed a fluoropolymer-based nanovaccine for tumor immunotherapy. Due to the existence of fluo...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-09, Vol.11 (37), p.8933-8942
Hauptverfasser:	Zhan, Yu-Rong, He, Xi, Huang, Zhi-Ying, Chen, Ping, Tian, Miao-Miao, Li, Guo-Hong, Yu, Xiao-Qi, Song, Xiang-Rong, Zhang, Ji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen presentation Antigens Cancer Cancer immunotherapy CD4 antigen CD8 antigen Dendritic cells Fluoropolymers Immunization Immunogenicity Immunotherapy Lymph nodes Lymphocytes Lymphocytes T Ovalbumin Proteins Ring opening polymerization Robustness Tumor necrosis factor-α Tumors γ-Interferon
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