design of peptides that bind specific conformers of α-synuclein

Insoluble amyloids rich in cross-β fibrils are observed in a number of neurodegenerative diseases. Depending on the clinicopathology, the amyloids can adopt distinct supramolecular assemblies, termed conformational strains. However, rapid methods to study amyloids in a conformationally specific mann...

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Veröffentlicht in:	Chemical science (Cambridge) 2024-06, Vol.15 (22), p.8414-8421
Hauptverfasser:	Wallace, Hailey M, Yang, Hyunjun, Tan, Sophia, Pan, Henry S, Yang, Rose, Xu, Junyi, Jo, Hyunil, Condello, Carlo, Polizzi, Nicholas F, DeGrado, William F
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