Rapid building block-economic synthesis of long, multi--GalNAcylated MUC5AC tandem repeat peptides

The study of mucin function requires access to highly O -glycosylated peptides with multiple tandem repeats. Solid-phase synthesis would be a suitable method, however, the central problem in the synthesis of mucin glycopeptides is the need to use precious and potentially vulnerable glycoamino acid b...

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Veröffentlicht in:Chemical science (Cambridge) 2024-01, Vol.15 (4), p.1297-135
Hauptverfasser: Galashov, Arseniy, Kazakova, Ekaterina, Stieger, Christian E, Hackenberger, Christian P. R, Seitz, Oliver
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