Determining the resolution of a tracer for magnetic particle imaging by means of magnetic particle spectroscopy
Magnetic particle imaging (MPI) is an imaging modality to quantitatively determine the three-dimensional distribution of magnetic nanoparticles (MNPs) administered as a tracer into a biological system. Magnetic particle spectroscopy (MPS) is the zero-dimensional MPI counterpart without spatial codin...
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| Veröffentlicht in: | RSC advances 2023-05, Vol.13 (23), p.1573-15736 |
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| container_title | RSC advances |
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| creator | Remmo, Amani Wiekhorst, Frank Kosch, Olaf Lyer, Stefan Unterweger, Harald Kratz, Harald Löwa, Norbert |
| description | Magnetic particle imaging (MPI) is an imaging modality to quantitatively determine the three-dimensional distribution of magnetic nanoparticles (MNPs) administered as a tracer into a biological system. Magnetic particle spectroscopy (MPS) is the zero-dimensional MPI counterpart without spatial coding but with much higher sensitivity. Generally, MPS is employed to qualitatively evaluate the MPI capability of tracer systems from the measured specific harmonic spectra. Here, we investigated the correlation of three characteristic MPS parameters with the achievable MPI resolution from a recently introduced procedure based on a two-voxel-analysis of data taken from the system function acquisition that is mandatory in Lissajous scanning MPI. We evaluated nine different tracer systems and determined their MPI capability and resolution from MPS measurements and compared the results with MPI phantom measurements.
We evaluated 9 tracers by magnetic particle spectroscopy to estimate their magnetic particle imaging capability and investigated the correlation of 3 MPS parameters and the hydrodynamic size distribution with the achievable MPI resolution
r
determined by two-voxel-analysis. |
| doi_str_mv | 10.1039/d3ra01394d |
| format | Article |
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We evaluated 9 tracers by magnetic particle spectroscopy to estimate their magnetic particle imaging capability and investigated the correlation of 3 MPS parameters and the hydrodynamic size distribution with the achievable MPI resolution
r
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We evaluated 9 tracers by magnetic particle spectroscopy to estimate their magnetic particle imaging capability and investigated the correlation of 3 MPS parameters and the hydrodynamic size distribution with the achievable MPI resolution
r
determined by two-voxel-analysis.</description><subject>Chemistry</subject><subject>Imaging</subject><subject>Nanoparticles</subject><subject>Spectroscopy</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNplkk1rGzEQhkVJaULqS-8tglxCwO1I2i-dionzUQgESnsWWu3I2bArbaTdgP995Nhxk0aXEZpnXt6ZESFfGHxnIOSPRgQNTMis-UCOOGTFnEMhD17dD8ksxntIp8gZL9gncihKLnIG2RHxSxwx9K1r3YqOd0gDRt9NY-sd9ZZqOgZtMFDrA-31yuHYGjrokEKHtE1Pm8J6TXvULm5K3lNxQDMGH40f1p_JR6u7iLNdPCZ_Ly_-nF_Pb26vfp0vbuYm43KcG16VySzWudVFk9cWmixDrK1F2VTaFlVlZZllpZa5BGNYDXXOSg2l1LXOjTgmP7e6w1T32Bh0qZFODSFZDmvldaveZlx7p1b-UTHgUKXRJYXTnULwDxPGUfVtNNh12qGfouIVB-BCgEjoyX_ovZ-CS_1tKMZLVnCeqLMtZdIsYkC7d8NAbXapluL34nmXywR_e-1_j75sLgFft0CIZp_99xnEE4sRpfQ</recordid><startdate>20230522</startdate><enddate>20230522</enddate><creator>Remmo, Amani</creator><creator>Wiekhorst, Frank</creator><creator>Kosch, Olaf</creator><creator>Lyer, Stefan</creator><creator>Unterweger, Harald</creator><creator>Kratz, Harald</creator><creator>Löwa, Norbert</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2338-1136</orcidid><orcidid>https://orcid.org/0000-0001-6245-9042</orcidid><orcidid>https://orcid.org/0000-0002-6740-8217</orcidid><orcidid>https://orcid.org/0000-0002-8335-0692</orcidid><orcidid>https://orcid.org/0000-0003-0608-1473</orcidid><orcidid>https://orcid.org/0000-0003-4171-5283</orcidid><orcidid>https://orcid.org/0000-0003-0126-0288</orcidid></search><sort><creationdate>20230522</creationdate><title>Determining the resolution of a tracer for magnetic particle imaging by means of magnetic particle spectroscopy</title><author>Remmo, Amani ; Wiekhorst, Frank ; Kosch, Olaf ; Lyer, Stefan ; Unterweger, Harald ; Kratz, Harald ; Löwa, Norbert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-c287512eb5fa6d5bf0d44eebffe9d8af688f97447a9590cc1b0b517a079aba5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chemistry</topic><topic>Imaging</topic><topic>Nanoparticles</topic><topic>Spectroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Remmo, Amani</creatorcontrib><creatorcontrib>Wiekhorst, Frank</creatorcontrib><creatorcontrib>Kosch, Olaf</creatorcontrib><creatorcontrib>Lyer, Stefan</creatorcontrib><creatorcontrib>Unterweger, Harald</creatorcontrib><creatorcontrib>Kratz, Harald</creatorcontrib><creatorcontrib>Löwa, Norbert</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remmo, Amani</au><au>Wiekhorst, Frank</au><au>Kosch, Olaf</au><au>Lyer, Stefan</au><au>Unterweger, Harald</au><au>Kratz, Harald</au><au>Löwa, Norbert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determining the resolution of a tracer for magnetic particle imaging by means of magnetic particle spectroscopy</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2023-05-22</date><risdate>2023</risdate><volume>13</volume><issue>23</issue><spage>1573</spage><epage>15736</epage><pages>1573-15736</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Magnetic particle imaging (MPI) is an imaging modality to quantitatively determine the three-dimensional distribution of magnetic nanoparticles (MNPs) administered as a tracer into a biological system. Magnetic particle spectroscopy (MPS) is the zero-dimensional MPI counterpart without spatial coding but with much higher sensitivity. Generally, MPS is employed to qualitatively evaluate the MPI capability of tracer systems from the measured specific harmonic spectra. Here, we investigated the correlation of three characteristic MPS parameters with the achievable MPI resolution from a recently introduced procedure based on a two-voxel-analysis of data taken from the system function acquisition that is mandatory in Lissajous scanning MPI. We evaluated nine different tracer systems and determined their MPI capability and resolution from MPS measurements and compared the results with MPI phantom measurements.
We evaluated 9 tracers by magnetic particle spectroscopy to estimate their magnetic particle imaging capability and investigated the correlation of 3 MPS parameters and the hydrodynamic size distribution with the achievable MPI resolution
r
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Chemistry Imaging Nanoparticles Spectroscopy |
| title | Determining the resolution of a tracer for magnetic particle imaging by means of magnetic particle spectroscopy |
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