A green synthesis of pyrimido[4,5-]quinolines and pyrido[2,3-]pyrimidines a mechanochemical approach

A green synthesis of pyrimido[4,5-]quinolines and pyrido[2,3-]pyrimidines a mechanochemical approach

A cost-effective and competent approach has been established for the synthesis of pyrimido[4,5- b ]quinolines and pyrido[2,3- d ]pyrimidines via a multicomponent reaction of 1,3 diketones (dimedone, barbituric acid, and Meldrum's acid), 6-aminouracil and aromatic aldehyde, through mechanochemic...

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Veröffentlicht in:Organic & biomolecular chemistry 2023-06, Vol.21 (23), p.4854-4862
Hauptverfasser: Singh, Himanshu Kumar, Kamal, Arsala, Maury, Suresh Kumar, Kushwaha, Ambuj Kumar, Srivastava, Vandana, Singh, Sundaram
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container_issue 23
container_start_page 4854
container_title Organic & biomolecular chemistry
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creator Singh, Himanshu Kumar
Kamal, Arsala
Maury, Suresh Kumar
Kushwaha, Ambuj Kumar
Srivastava, Vandana
Singh, Sundaram
description A cost-effective and competent approach has been established for the synthesis of pyrimido[4,5- b ]quinolines and pyrido[2,3- d ]pyrimidines via a multicomponent reaction of 1,3 diketones (dimedone, barbituric acid, and Meldrum's acid), 6-aminouracil and aromatic aldehyde, through mechanochemical synthesis using a ball-mill. This transformation involves a one pot, catalyst-free, and solvent-free pathway to develop the desired products under mild reaction conditions. A green synthesis of pyrimido[4,5- b ]quinolines and pyrido[2,3- d ]pyrimidines via a multicomponent reaction of 1,3 diketones (dimedone, barbituric acid, and Meldrum's acid), 6-aminouracil and aromatic aldehyde, through mechanochemical synthesis using a ball-mill.
doi_str_mv 10.1039/d3ob00626c
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title A green synthesis of pyrimido[4,5-]quinolines and pyrido[2,3-]pyrimidines a mechanochemical approach
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