Cyclization of -Boc-()-α,β-unsaturated γ-amino acid active esters into -Boc-()-α,β-unsaturated γ-lactams through → isomerization

Here, we are reporting the spontaneous transformation of the active esters of N -Boc protected E -α,β-unsaturated γ-amino acids into the corresponding Z -α,β-unsaturated γ-lactams with concomitant E → Z isomerization in the presence of a weak base. No cyclization was observed in the absence of the b...

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Veröffentlicht in:	Organic & biomolecular chemistry 2023-05, Vol.21 (18), p.3766-3769
Hauptverfasser:	Singh, Manjeet, Kumar, Manish, Nalawade, Sachin A, Puneeth Kumar, DRGKoppalu R, Gopi, Hosahudya N
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