A study of complexation and biological fate of polyethyleneimine-siRNA polyplexes and by fluorescence correlation spectroscopy and positron emission tomography imaging

A deeper knowledge on the formation and biological fate of polymer based gene vectors is needed for their translation into therapy. Here, polyplexes of polyethyleneimine (PEI) and silencing RNA (siRNA) are formed with theoretical N/P ratios of 2, 4 and 12. Fluorescence correlation spectroscopy (FCS)...

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Veröffentlicht in:	Nanoscale 2024-02, Vol.16 (7), p.3525-3533
Hauptverfasser:	Ludtke, Tanja, Simó, Cristina, Gimenez Reyes, Santiago, Martinez Moro, Marta, Salvador, Cristian, Ritacco, Hernan, Andreozzi, Patrizia, Llop, Jordi, Moya, Sergio E
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