Carboxymethylcellulose modified FeO@SiO@GdPO:Tb,Ce nanocomposites for combined optical and magnetic fluid hyperthermia in cancer therapy
A stepwise synthetic method is reported for the synthesis of multifunctional, magnetic and luminescent composites with silica-coated Fe 3 O 4 as the core and Ce 3+ sensitized Tb 3+ doped GdPO 4 embedded in carboxymethylcellulose. The phase composition, infrared spectra, luminescence and magnetic pro...
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Veröffentlicht in: | RSC applied interfaces 2024-03, Vol.1 (2), p.313-322 |
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creator | Yengkhom, Dhanapriya Devi Ningombam, Goutam Singh Heisnam, Rameshwari Sharma, Nanaocha Nongmaithem, Rajmuhon Singh Chipem, Francis A. S |
description | A stepwise synthetic method is reported for the synthesis of multifunctional, magnetic and luminescent composites with silica-coated Fe
3
O
4
as the core and Ce
3+
sensitized Tb
3+
doped GdPO
4
embedded in carboxymethylcellulose. The phase composition, infrared spectra, luminescence and magnetic properties were characterized by X-ray diffraction, FTIR, photoluminescence spectroscopy and vibrating sample magnetometry, respectively. The synthesized materials exhibit high saturation magnetization and excellent luminescence properties. The composites show intense green emission at 545 nm upon excitation at 276 nm. They attain the hyperthermia temperature (∼42 °C) within the threshold alternating magnetic field (5 × 10
6
kA m
−1
s
−1
). The samples exhibit efficient induction heating properties which is highly desirable for magnetic hyperthermia application in cancer therapy. The materials are found to have excellent biocompatibility towards the MDA-231 breast cancer cell line and A549 lung cancer cell line with their
in vitro
cell viability showing 50% and 90%, respectively, for up to 200 μg mL
−1
concentration, and the IC
50
values reaching 154.33 ± 18.06 μg mL
−1
and 667.45 ± 20.03 μg mL
−1
, respectively. The synthesized multifunctional magnetic luminescent nanocomposites provide a new insight for optical imaging and therapeutic agents for hyperthermia cancer therapy.
A stepwise synthetic method is reported for the synthesis of multifunctional, magnetic and luminescent composites with silica-coated Fe
3
O
4
as the core and Ce
3+
sensitized Tb
3+
doped GdPO
4
embedded in carboxymethylcellulose. |
doi_str_mv | 10.1039/d3lf00217a |
format | Article |
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3
O
4
as the core and Ce
3+
sensitized Tb
3+
doped GdPO
4
embedded in carboxymethylcellulose. The phase composition, infrared spectra, luminescence and magnetic properties were characterized by X-ray diffraction, FTIR, photoluminescence spectroscopy and vibrating sample magnetometry, respectively. The synthesized materials exhibit high saturation magnetization and excellent luminescence properties. The composites show intense green emission at 545 nm upon excitation at 276 nm. They attain the hyperthermia temperature (∼42 °C) within the threshold alternating magnetic field (5 × 10
6
kA m
−1
s
−1
). The samples exhibit efficient induction heating properties which is highly desirable for magnetic hyperthermia application in cancer therapy. The materials are found to have excellent biocompatibility towards the MDA-231 breast cancer cell line and A549 lung cancer cell line with their
in vitro
cell viability showing 50% and 90%, respectively, for up to 200 μg mL
−1
concentration, and the IC
50
values reaching 154.33 ± 18.06 μg mL
−1
and 667.45 ± 20.03 μg mL
−1
, respectively. The synthesized multifunctional magnetic luminescent nanocomposites provide a new insight for optical imaging and therapeutic agents for hyperthermia cancer therapy.
A stepwise synthetic method is reported for the synthesis of multifunctional, magnetic and luminescent composites with silica-coated Fe
3
O
4
as the core and Ce
3+
sensitized Tb
3+
doped GdPO
4
embedded in carboxymethylcellulose.</description><identifier>EISSN: 2755-3701</identifier><identifier>DOI: 10.1039/d3lf00217a</identifier><ispartof>RSC applied interfaces, 2024-03, Vol.1 (2), p.313-322</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Yengkhom, Dhanapriya Devi</creatorcontrib><creatorcontrib>Ningombam, Goutam Singh</creatorcontrib><creatorcontrib>Heisnam, Rameshwari</creatorcontrib><creatorcontrib>Sharma, Nanaocha</creatorcontrib><creatorcontrib>Nongmaithem, Rajmuhon Singh</creatorcontrib><creatorcontrib>Chipem, Francis A. S</creatorcontrib><title>Carboxymethylcellulose modified FeO@SiO@GdPO:Tb,Ce nanocomposites for combined optical and magnetic fluid hyperthermia in cancer therapy</title><title>RSC applied interfaces</title><description>A stepwise synthetic method is reported for the synthesis of multifunctional, magnetic and luminescent composites with silica-coated Fe
3
O
4
as the core and Ce
3+
sensitized Tb
3+
doped GdPO
4
embedded in carboxymethylcellulose. The phase composition, infrared spectra, luminescence and magnetic properties were characterized by X-ray diffraction, FTIR, photoluminescence spectroscopy and vibrating sample magnetometry, respectively. The synthesized materials exhibit high saturation magnetization and excellent luminescence properties. The composites show intense green emission at 545 nm upon excitation at 276 nm. They attain the hyperthermia temperature (∼42 °C) within the threshold alternating magnetic field (5 × 10
6
kA m
−1
s
−1
). The samples exhibit efficient induction heating properties which is highly desirable for magnetic hyperthermia application in cancer therapy. The materials are found to have excellent biocompatibility towards the MDA-231 breast cancer cell line and A549 lung cancer cell line with their
in vitro
cell viability showing 50% and 90%, respectively, for up to 200 μg mL
−1
concentration, and the IC
50
values reaching 154.33 ± 18.06 μg mL
−1
and 667.45 ± 20.03 μg mL
−1
, respectively. The synthesized multifunctional magnetic luminescent nanocomposites provide a new insight for optical imaging and therapeutic agents for hyperthermia cancer therapy.
A stepwise synthetic method is reported for the synthesis of multifunctional, magnetic and luminescent composites with silica-coated Fe
3
O
4
as the core and Ce
3+
sensitized Tb
3+
doped GdPO
4
embedded in carboxymethylcellulose.</description><issn>2755-3701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFj81KAzEUhYMgWLQb98J9AKvJpGWoq8JgdTcFuy93khsnkj-SKZg38LEdQXDp6vCd72wOY7eCPwgut49aOsN5I1q8YIum3WxWsuXiii1L-eCcSyma7Xq9YF8d5iF-Vk_TWJ0i584uFgIftTWWNOyp373ZfveiD_3TcbjvCAKGqKJPsdiJCpiYYcbBhnke02QVOsCgweN7oBnBuLPVMNZEeRope4tgAygMijL8NJjqDbs06Aotf_Oa3e2fj93rKhd1Stl6zPX090r-578BuxBUzw</recordid><startdate>20240312</startdate><enddate>20240312</enddate><creator>Yengkhom, Dhanapriya Devi</creator><creator>Ningombam, Goutam Singh</creator><creator>Heisnam, Rameshwari</creator><creator>Sharma, Nanaocha</creator><creator>Nongmaithem, Rajmuhon Singh</creator><creator>Chipem, Francis A. S</creator><scope/></search><sort><creationdate>20240312</creationdate><title>Carboxymethylcellulose modified FeO@SiO@GdPO:Tb,Ce nanocomposites for combined optical and magnetic fluid hyperthermia in cancer therapy</title><author>Yengkhom, Dhanapriya Devi ; Ningombam, Goutam Singh ; Heisnam, Rameshwari ; Sharma, Nanaocha ; Nongmaithem, Rajmuhon Singh ; Chipem, Francis A. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_d3lf00217a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yengkhom, Dhanapriya Devi</creatorcontrib><creatorcontrib>Ningombam, Goutam Singh</creatorcontrib><creatorcontrib>Heisnam, Rameshwari</creatorcontrib><creatorcontrib>Sharma, Nanaocha</creatorcontrib><creatorcontrib>Nongmaithem, Rajmuhon Singh</creatorcontrib><creatorcontrib>Chipem, Francis A. S</creatorcontrib><jtitle>RSC applied interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yengkhom, Dhanapriya Devi</au><au>Ningombam, Goutam Singh</au><au>Heisnam, Rameshwari</au><au>Sharma, Nanaocha</au><au>Nongmaithem, Rajmuhon Singh</au><au>Chipem, Francis A. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carboxymethylcellulose modified FeO@SiO@GdPO:Tb,Ce nanocomposites for combined optical and magnetic fluid hyperthermia in cancer therapy</atitle><jtitle>RSC applied interfaces</jtitle><date>2024-03-12</date><risdate>2024</risdate><volume>1</volume><issue>2</issue><spage>313</spage><epage>322</epage><pages>313-322</pages><eissn>2755-3701</eissn><abstract>A stepwise synthetic method is reported for the synthesis of multifunctional, magnetic and luminescent composites with silica-coated Fe
3
O
4
as the core and Ce
3+
sensitized Tb
3+
doped GdPO
4
embedded in carboxymethylcellulose. The phase composition, infrared spectra, luminescence and magnetic properties were characterized by X-ray diffraction, FTIR, photoluminescence spectroscopy and vibrating sample magnetometry, respectively. The synthesized materials exhibit high saturation magnetization and excellent luminescence properties. The composites show intense green emission at 545 nm upon excitation at 276 nm. They attain the hyperthermia temperature (∼42 °C) within the threshold alternating magnetic field (5 × 10
6
kA m
−1
s
−1
). The samples exhibit efficient induction heating properties which is highly desirable for magnetic hyperthermia application in cancer therapy. The materials are found to have excellent biocompatibility towards the MDA-231 breast cancer cell line and A549 lung cancer cell line with their
in vitro
cell viability showing 50% and 90%, respectively, for up to 200 μg mL
−1
concentration, and the IC
50
values reaching 154.33 ± 18.06 μg mL
−1
and 667.45 ± 20.03 μg mL
−1
, respectively. The synthesized multifunctional magnetic luminescent nanocomposites provide a new insight for optical imaging and therapeutic agents for hyperthermia cancer therapy.
A stepwise synthetic method is reported for the synthesis of multifunctional, magnetic and luminescent composites with silica-coated Fe
3
O
4
as the core and Ce
3+
sensitized Tb
3+
doped GdPO
4
embedded in carboxymethylcellulose.</abstract><doi>10.1039/d3lf00217a</doi><tpages>1</tpages></addata></record> |
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ispartof | RSC applied interfaces, 2024-03, Vol.1 (2), p.313-322 |
issn | 2755-3701 |
language | |
recordid | cdi_rsc_primary_d3lf00217a |
source | DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
title | Carboxymethylcellulose modified FeO@SiO@GdPO:Tb,Ce nanocomposites for combined optical and magnetic fluid hyperthermia in cancer therapy |
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