Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice
A high-sugar and -fat diet (HSFD) has become a primary risk factor for diabetes, and dietary intervention shows a substantial effect on the prevention and management of hyperglycemia. In this study, the chemical compositions of the aqueous extracts of stir-fried green tea (GT) and congou black tea (...
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| Veröffentlicht in: | Food & function 2023-05, Vol.14 (9), p.4327-4338 |
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| creator | Zhou, Hui Li, Fanglan Wu, Meirong Zhu, Jiangxiong Wang, Yuanfeng Wei, Xinlin |
| description | A high-sugar and -fat diet (HSFD) has become a primary risk factor for diabetes, and dietary intervention shows a substantial effect on the prevention and management of hyperglycemia. In this study, the chemical compositions of the aqueous extracts of stir-fried green tea (GT) and congou black tea (BT) were compared. Moreover, their potential mechanisms and regulatory effects on hepatic glycolipid metabolism and gut microbiota disorders in hyperglycemic mice were further explored. Our results show that GT or BT intervention had a prominent regulatory effect on glycolipid metabolism. Moreover, they could significantly regulate the levels of serum metabolic signatures, the activities of key enzymes in liver glucose metabolism, and the expression of genes or proteins related to glycolipid metabolism
via
activating the IRS-1-PI3K/AKT-GLUT2 signaling pathway. Significantly, GT or BT administration adjusted the composition and diversity of the gut microbiota, mainly reflecting a significant increase in the abundance of beneficial bacteria (including
Allobaculum
,
Lactobacillus
, and
Turicibacter
) and reducing the abundance of harmful or conditionally pathogenic bacteria (mainly including Clostridiales and
Bacteroides
). Our results suggest that dietary supplementation with GT or BT could exert a practical anti-diabetic effect. Meanwhile, BT intervention showed a better regulation effect on glycolipid metabolism. This study reveals that GT and BT have excellent potential for developing anti-diabetic food.
A high-sugar and -fat diet (HSFD) has become a primary risk factor for diabetes, and dietary intervention shows a substantial effect on the prevention and management of hyperglycemia. |
| doi_str_mv | 10.1039/d3fo00355h |
| format | Article |
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via
activating the IRS-1-PI3K/AKT-GLUT2 signaling pathway. Significantly, GT or BT administration adjusted the composition and diversity of the gut microbiota, mainly reflecting a significant increase in the abundance of beneficial bacteria (including
Allobaculum
,
Lactobacillus
, and
Turicibacter
) and reducing the abundance of harmful or conditionally pathogenic bacteria (mainly including Clostridiales and
Bacteroides
). Our results suggest that dietary supplementation with GT or BT could exert a practical anti-diabetic effect. Meanwhile, BT intervention showed a better regulation effect on glycolipid metabolism. This study reveals that GT and BT have excellent potential for developing anti-diabetic food.
A high-sugar and -fat diet (HSFD) has become a primary risk factor for diabetes, and dietary intervention shows a substantial effect on the prevention and management of hyperglycemia.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d3fo00355h</identifier><identifier>PMID: 37083054</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>1-Phosphatidylinositol 3-kinase ; Abundance ; AKT protein ; Animals ; Bacteria ; Black tea ; Camellia sinensis - chemistry ; Chemical composition ; Diabetes ; Diabetes mellitus ; Diet ; Diet, High-Fat - adverse effects ; Dietary supplements ; Gastrointestinal Microbiome ; Gene expression ; Glucose metabolism ; Glucose transporter ; Glycolipids - pharmacology ; Green tea ; Health risks ; High fat diet ; Hyperglycemia ; Intestinal microflora ; Metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Microbiota ; Microorganisms ; Phosphatidylinositol 3-Kinases ; Probiotics ; Regulation ; Risk factors ; Signal transduction ; Tea - chemistry</subject><ispartof>Food & function, 2023-05, Vol.14 (9), p.4327-4338</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-e0a3519650cc3eed48b57a5198346f6196c389ed7bc736201367742d633578ef3</citedby><cites>FETCH-LOGICAL-c337t-e0a3519650cc3eed48b57a5198346f6196c389ed7bc736201367742d633578ef3</cites><orcidid>0000-0003-3743-4008</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37083054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Hui</creatorcontrib><creatorcontrib>Li, Fanglan</creatorcontrib><creatorcontrib>Wu, Meirong</creatorcontrib><creatorcontrib>Zhu, Jiangxiong</creatorcontrib><creatorcontrib>Wang, Yuanfeng</creatorcontrib><creatorcontrib>Wei, Xinlin</creatorcontrib><title>Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>A high-sugar and -fat diet (HSFD) has become a primary risk factor for diabetes, and dietary intervention shows a substantial effect on the prevention and management of hyperglycemia. In this study, the chemical compositions of the aqueous extracts of stir-fried green tea (GT) and congou black tea (BT) were compared. Moreover, their potential mechanisms and regulatory effects on hepatic glycolipid metabolism and gut microbiota disorders in hyperglycemic mice were further explored. Our results show that GT or BT intervention had a prominent regulatory effect on glycolipid metabolism. Moreover, they could significantly regulate the levels of serum metabolic signatures, the activities of key enzymes in liver glucose metabolism, and the expression of genes or proteins related to glycolipid metabolism
via
activating the IRS-1-PI3K/AKT-GLUT2 signaling pathway. Significantly, GT or BT administration adjusted the composition and diversity of the gut microbiota, mainly reflecting a significant increase in the abundance of beneficial bacteria (including
Allobaculum
,
Lactobacillus
, and
Turicibacter
) and reducing the abundance of harmful or conditionally pathogenic bacteria (mainly including Clostridiales and
Bacteroides
). Our results suggest that dietary supplementation with GT or BT could exert a practical anti-diabetic effect. Meanwhile, BT intervention showed a better regulation effect on glycolipid metabolism. This study reveals that GT and BT have excellent potential for developing anti-diabetic food.
A high-sugar and -fat diet (HSFD) has become a primary risk factor for diabetes, and dietary intervention shows a substantial effect on the prevention and management of hyperglycemia.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Abundance</subject><subject>AKT protein</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Black tea</subject><subject>Camellia sinensis - chemistry</subject><subject>Chemical composition</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dietary supplements</subject><subject>Gastrointestinal Microbiome</subject><subject>Gene expression</subject><subject>Glucose metabolism</subject><subject>Glucose transporter</subject><subject>Glycolipids - pharmacology</subject><subject>Green tea</subject><subject>Health risks</subject><subject>High fat diet</subject><subject>Hyperglycemia</subject><subject>Intestinal microflora</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Obese</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Phosphatidylinositol 3-Kinases</subject><subject>Probiotics</subject><subject>Regulation</subject><subject>Risk factors</subject><subject>Signal transduction</subject><subject>Tea - chemistry</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1LxDAQhoMo7rLuxbsS8CJCNe2kX0dZXVdYWBAFbyVNp92ubVOT9tB_b_ZLwbnMkPeZYfIOIZcuu3cZxA8Z5Iox8P31CRl7jHtO4LPP02PN42BEpsZsmA2I4yiOzskIQhYB8_mYZG9Y9JXoStVQldOi6qWqyrbMaI2dSG1taiqajBZ9R-tSapWWqhM0HWihEZudllZCftEOhaFlQ9dDi7qoBomW3_bgBTnLRWVwesgT8jF_fp8tnOXq5XX2uHQkQNg5yAT4bmz3lxIQMx6lfijsSwQ8yAOrSIhizMJUhhB4zIUgDLmXBQB-GGEOE3K7n9tq9d2j6ZK6NBKrSjSoepN4EfMZcI-DRW_-oRvV68ZuZynXjbkHLLDU3Z6y_zZGY560uqyFHhKXJVv7kyeYr3b2Lyx8fRjZpzVmv-jRbAtc7QFt5K_6dz_4AWVYiDs</recordid><startdate>20230511</startdate><enddate>20230511</enddate><creator>Zhou, Hui</creator><creator>Li, Fanglan</creator><creator>Wu, Meirong</creator><creator>Zhu, Jiangxiong</creator><creator>Wang, Yuanfeng</creator><creator>Wei, Xinlin</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3743-4008</orcidid></search><sort><creationdate>20230511</creationdate><title>Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice</title><author>Zhou, Hui ; Li, Fanglan ; Wu, Meirong ; Zhu, Jiangxiong ; Wang, Yuanfeng ; Wei, Xinlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-e0a3519650cc3eed48b57a5198346f6196c389ed7bc736201367742d633578ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>Abundance</topic><topic>AKT protein</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Black tea</topic><topic>Camellia sinensis - chemistry</topic><topic>Chemical composition</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Dietary supplements</topic><topic>Gastrointestinal Microbiome</topic><topic>Gene expression</topic><topic>Glucose metabolism</topic><topic>Glucose transporter</topic><topic>Glycolipids - pharmacology</topic><topic>Green tea</topic><topic>Health risks</topic><topic>High fat diet</topic><topic>Hyperglycemia</topic><topic>Intestinal microflora</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Obese</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Phosphatidylinositol 3-Kinases</topic><topic>Probiotics</topic><topic>Regulation</topic><topic>Risk factors</topic><topic>Signal transduction</topic><topic>Tea - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Hui</creatorcontrib><creatorcontrib>Li, Fanglan</creatorcontrib><creatorcontrib>Wu, Meirong</creatorcontrib><creatorcontrib>Zhu, Jiangxiong</creatorcontrib><creatorcontrib>Wang, Yuanfeng</creatorcontrib><creatorcontrib>Wei, Xinlin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Hui</au><au>Li, Fanglan</au><au>Wu, Meirong</au><au>Zhu, Jiangxiong</au><au>Wang, Yuanfeng</au><au>Wei, Xinlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2023-05-11</date><risdate>2023</risdate><volume>14</volume><issue>9</issue><spage>4327</spage><epage>4338</epage><pages>4327-4338</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>A high-sugar and -fat diet (HSFD) has become a primary risk factor for diabetes, and dietary intervention shows a substantial effect on the prevention and management of hyperglycemia. In this study, the chemical compositions of the aqueous extracts of stir-fried green tea (GT) and congou black tea (BT) were compared. Moreover, their potential mechanisms and regulatory effects on hepatic glycolipid metabolism and gut microbiota disorders in hyperglycemic mice were further explored. Our results show that GT or BT intervention had a prominent regulatory effect on glycolipid metabolism. Moreover, they could significantly regulate the levels of serum metabolic signatures, the activities of key enzymes in liver glucose metabolism, and the expression of genes or proteins related to glycolipid metabolism
via
activating the IRS-1-PI3K/AKT-GLUT2 signaling pathway. Significantly, GT or BT administration adjusted the composition and diversity of the gut microbiota, mainly reflecting a significant increase in the abundance of beneficial bacteria (including
Allobaculum
,
Lactobacillus
, and
Turicibacter
) and reducing the abundance of harmful or conditionally pathogenic bacteria (mainly including Clostridiales and
Bacteroides
). Our results suggest that dietary supplementation with GT or BT could exert a practical anti-diabetic effect. Meanwhile, BT intervention showed a better regulation effect on glycolipid metabolism. This study reveals that GT and BT have excellent potential for developing anti-diabetic food.
A high-sugar and -fat diet (HSFD) has become a primary risk factor for diabetes, and dietary intervention shows a substantial effect on the prevention and management of hyperglycemia.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37083054</pmid><doi>10.1039/d3fo00355h</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-3743-4008</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2023-05, Vol.14 (9), p.4327-4338 |
| issn | 2042-6496 2042-650X |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | 1-Phosphatidylinositol 3-kinase Abundance AKT protein Animals Bacteria Black tea Camellia sinensis - chemistry Chemical composition Diabetes Diabetes mellitus Diet Diet, High-Fat - adverse effects Dietary supplements Gastrointestinal Microbiome Gene expression Glucose metabolism Glucose transporter Glycolipids - pharmacology Green tea Health risks High fat diet Hyperglycemia Intestinal microflora Metabolism Mice Mice, Inbred C57BL Mice, Obese Microbiota Microorganisms Phosphatidylinositol 3-Kinases Probiotics Regulation Risk factors Signal transduction Tea - chemistry |
| title | Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice |
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