Isolation of potassium salt of oxadiazole-2-thione and anticancer activities of its Cu() and Zn() complexes against MDA-MB-231 human breast carcinoma cells
A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en) 2 (pot) 2 ] ( 1 ) and [Zn(en) 2 (pot) 2 ]HBr·CH 3 OH ( 2 ) containing ethylenediamine (en) as secondary ligand were synthesized and fully characterized. Upon changing the reaction conditions,...
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2023-07, Vol.52 (29), p.1213-1221 |
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| container_title | Dalton transactions : an international journal of inorganic chemistry |
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| creator | Gond, M. K Rai, Nilesh Chandra, Brijesh Gautam, Vibhav Garai, Somenath Butcher, R. J Bharty, M. K |
| description | A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)
2
(pot)
2
] (
1
) and [Zn(en)
2
(pot)
2
]HBr·CH
3
OH (
2
) containing ethylenediamine (en) as secondary ligand were synthesized and fully characterized. Upon changing the reaction conditions, the Cu(
ii
) complex (
1
) adopts an octahedral geometry around the metal center. The cytotoxic activity of ligand (Kpot·H
2
O) along with complexes
1
and
2
was tested, and their anticancer activity against MDA-MB-231 human breast cancer cells was demonstrated, with complex
1
exhibiting superior cytotoxicity against these cells as compared to Kpot·H
2
O and complex
2
. According to the DNA nicking assay, the ligand (Kpot·H
2
O) was found to be more potent to scavenge hydroxyl radicals even at a lower concentration (50 μg mL
−1
) than that of both complexes. The wound healing assay revealed that ligand Kpot·H
2
O and its complexes
1
and
2
attenuated the migration of the above-mentioned cell line. The loss of cellular and nuclear integrity and induction in the activity of Caspase-3 suggest the anticancer potential of ligand Kpot·H
2
O and its complexes
1
and
2
against MDA-MB-231 cells.
A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)
2
(pot)
2
] (
1
) and [Zn(en)
2
(pot)
2
]HBr·CH
3
OH (
2
) containing ethylenediamine (en) as secondary ligands were synthesized and fully characterized. |
| doi_str_mv | 10.1039/d3dt01388j |
| format | Article |
| fullrecord | <record><control><sourceid>rsc</sourceid><recordid>TN_cdi_rsc_primary_d3dt01388j</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>d3dt01388j</sourcerecordid><originalsourceid>FETCH-rsc_primary_d3dt01388j3</originalsourceid><addsrcrecordid>eNqFT7tOAzEQtBBIhEdDj-QSCoMfgSQlJCAo0lHRRIvPIRv57JN3DwV-hZ_FQQhKitGM5lGMECdGXxjtJpeNa1gbNx6vd8TADEcjNbFuuPur7fW-OCBaa22tvrID8flIOQJjTjIvZZcZiLBvJUHkrZM30CB85BiUVbyqvSAhNRWMHpIPRYJnfEPGQNsBMslpf3b-3XpOVfjcdjFsagyvgIlYzmc3an6rrDNy1beQ5EsJUH0PxWPKLUgfYqQjsbeESOH4hw_F6f3d0_RBFfKLrmAL5X3x99j9l38B9A9amA</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Isolation of potassium salt of oxadiazole-2-thione and anticancer activities of its Cu() and Zn() complexes against MDA-MB-231 human breast carcinoma cells</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Gond, M. K ; Rai, Nilesh ; Chandra, Brijesh ; Gautam, Vibhav ; Garai, Somenath ; Butcher, R. J ; Bharty, M. K</creator><creatorcontrib>Gond, M. K ; Rai, Nilesh ; Chandra, Brijesh ; Gautam, Vibhav ; Garai, Somenath ; Butcher, R. J ; Bharty, M. K</creatorcontrib><description>A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)
2
(pot)
2
] (
1
) and [Zn(en)
2
(pot)
2
]HBr·CH
3
OH (
2
) containing ethylenediamine (en) as secondary ligand were synthesized and fully characterized. Upon changing the reaction conditions, the Cu(
ii
) complex (
1
) adopts an octahedral geometry around the metal center. The cytotoxic activity of ligand (Kpot·H
2
O) along with complexes
1
and
2
was tested, and their anticancer activity against MDA-MB-231 human breast cancer cells was demonstrated, with complex
1
exhibiting superior cytotoxicity against these cells as compared to Kpot·H
2
O and complex
2
. According to the DNA nicking assay, the ligand (Kpot·H
2
O) was found to be more potent to scavenge hydroxyl radicals even at a lower concentration (50 μg mL
−1
) than that of both complexes. The wound healing assay revealed that ligand Kpot·H
2
O and its complexes
1
and
2
attenuated the migration of the above-mentioned cell line. The loss of cellular and nuclear integrity and induction in the activity of Caspase-3 suggest the anticancer potential of ligand Kpot·H
2
O and its complexes
1
and
2
against MDA-MB-231 cells.
A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)
2
(pot)
2
] (
1
) and [Zn(en)
2
(pot)
2
]HBr·CH
3
OH (
2
) containing ethylenediamine (en) as secondary ligands were synthesized and fully characterized.</description><identifier>ISSN: 1477-9226</identifier><identifier>EISSN: 1477-9234</identifier><identifier>DOI: 10.1039/d3dt01388j</identifier><ispartof>Dalton transactions : an international journal of inorganic chemistry, 2023-07, Vol.52 (29), p.1213-1221</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Gond, M. K</creatorcontrib><creatorcontrib>Rai, Nilesh</creatorcontrib><creatorcontrib>Chandra, Brijesh</creatorcontrib><creatorcontrib>Gautam, Vibhav</creatorcontrib><creatorcontrib>Garai, Somenath</creatorcontrib><creatorcontrib>Butcher, R. J</creatorcontrib><creatorcontrib>Bharty, M. K</creatorcontrib><title>Isolation of potassium salt of oxadiazole-2-thione and anticancer activities of its Cu() and Zn() complexes against MDA-MB-231 human breast carcinoma cells</title><title>Dalton transactions : an international journal of inorganic chemistry</title><description>A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)
2
(pot)
2
] (
1
) and [Zn(en)
2
(pot)
2
]HBr·CH
3
OH (
2
) containing ethylenediamine (en) as secondary ligand were synthesized and fully characterized. Upon changing the reaction conditions, the Cu(
ii
) complex (
1
) adopts an octahedral geometry around the metal center. The cytotoxic activity of ligand (Kpot·H
2
O) along with complexes
1
and
2
was tested, and their anticancer activity against MDA-MB-231 human breast cancer cells was demonstrated, with complex
1
exhibiting superior cytotoxicity against these cells as compared to Kpot·H
2
O and complex
2
. According to the DNA nicking assay, the ligand (Kpot·H
2
O) was found to be more potent to scavenge hydroxyl radicals even at a lower concentration (50 μg mL
−1
) than that of both complexes. The wound healing assay revealed that ligand Kpot·H
2
O and its complexes
1
and
2
attenuated the migration of the above-mentioned cell line. The loss of cellular and nuclear integrity and induction in the activity of Caspase-3 suggest the anticancer potential of ligand Kpot·H
2
O and its complexes
1
and
2
against MDA-MB-231 cells.
A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)
2
(pot)
2
] (
1
) and [Zn(en)
2
(pot)
2
]HBr·CH
3
OH (
2
) containing ethylenediamine (en) as secondary ligands were synthesized and fully characterized.</description><issn>1477-9226</issn><issn>1477-9234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFT7tOAzEQtBBIhEdDj-QSCoMfgSQlJCAo0lHRRIvPIRv57JN3DwV-hZ_FQQhKitGM5lGMECdGXxjtJpeNa1gbNx6vd8TADEcjNbFuuPur7fW-OCBaa22tvrID8flIOQJjTjIvZZcZiLBvJUHkrZM30CB85BiUVbyqvSAhNRWMHpIPRYJnfEPGQNsBMslpf3b-3XpOVfjcdjFsagyvgIlYzmc3an6rrDNy1beQ5EsJUH0PxWPKLUgfYqQjsbeESOH4hw_F6f3d0_RBFfKLrmAL5X3x99j9l38B9A9amA</recordid><startdate>20230725</startdate><enddate>20230725</enddate><creator>Gond, M. K</creator><creator>Rai, Nilesh</creator><creator>Chandra, Brijesh</creator><creator>Gautam, Vibhav</creator><creator>Garai, Somenath</creator><creator>Butcher, R. J</creator><creator>Bharty, M. K</creator><scope/></search><sort><creationdate>20230725</creationdate><title>Isolation of potassium salt of oxadiazole-2-thione and anticancer activities of its Cu() and Zn() complexes against MDA-MB-231 human breast carcinoma cells</title><author>Gond, M. K ; Rai, Nilesh ; Chandra, Brijesh ; Gautam, Vibhav ; Garai, Somenath ; Butcher, R. J ; Bharty, M. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_d3dt01388j3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gond, M. K</creatorcontrib><creatorcontrib>Rai, Nilesh</creatorcontrib><creatorcontrib>Chandra, Brijesh</creatorcontrib><creatorcontrib>Gautam, Vibhav</creatorcontrib><creatorcontrib>Garai, Somenath</creatorcontrib><creatorcontrib>Butcher, R. J</creatorcontrib><creatorcontrib>Bharty, M. K</creatorcontrib><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gond, M. K</au><au>Rai, Nilesh</au><au>Chandra, Brijesh</au><au>Gautam, Vibhav</au><au>Garai, Somenath</au><au>Butcher, R. J</au><au>Bharty, M. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation of potassium salt of oxadiazole-2-thione and anticancer activities of its Cu() and Zn() complexes against MDA-MB-231 human breast carcinoma cells</atitle><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle><date>2023-07-25</date><risdate>2023</risdate><volume>52</volume><issue>29</issue><spage>1213</spage><epage>1221</epage><pages>1213-1221</pages><issn>1477-9226</issn><eissn>1477-9234</eissn><abstract>A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)
2
(pot)
2
] (
1
) and [Zn(en)
2
(pot)
2
]HBr·CH
3
OH (
2
) containing ethylenediamine (en) as secondary ligand were synthesized and fully characterized. Upon changing the reaction conditions, the Cu(
ii
) complex (
1
) adopts an octahedral geometry around the metal center. The cytotoxic activity of ligand (Kpot·H
2
O) along with complexes
1
and
2
was tested, and their anticancer activity against MDA-MB-231 human breast cancer cells was demonstrated, with complex
1
exhibiting superior cytotoxicity against these cells as compared to Kpot·H
2
O and complex
2
. According to the DNA nicking assay, the ligand (Kpot·H
2
O) was found to be more potent to scavenge hydroxyl radicals even at a lower concentration (50 μg mL
−1
) than that of both complexes. The wound healing assay revealed that ligand Kpot·H
2
O and its complexes
1
and
2
attenuated the migration of the above-mentioned cell line. The loss of cellular and nuclear integrity and induction in the activity of Caspase-3 suggest the anticancer potential of ligand Kpot·H
2
O and its complexes
1
and
2
against MDA-MB-231 cells.
A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)
2
(pot)
2
] (
1
) and [Zn(en)
2
(pot)
2
]HBr·CH
3
OH (
2
) containing ethylenediamine (en) as secondary ligands were synthesized and fully characterized.</abstract><doi>10.1039/d3dt01388j</doi><tpages>9</tpages></addata></record> |
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| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2023-07, Vol.52 (29), p.1213-1221 |
| issn | 1477-9226 1477-9234 |
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| recordid | cdi_rsc_primary_d3dt01388j |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Isolation of potassium salt of oxadiazole-2-thione and anticancer activities of its Cu() and Zn() complexes against MDA-MB-231 human breast carcinoma cells |
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