Vicinal stereocenters asymmetric allylic alkylation and Cope rearrangement: a straightforward route to functionally and stereochemically rich heterocycles

An asymmetric allylic alkylation/Cope rearrangement (AAA/[3,3]) capable of stereoselectively constructing vicinal stereocenters has been developed. Strategically integrated 4-methylation on the 3,3-dicyano-1,5-diene controls stereoselectivity and drives Cope rearrangement equilibrium in the forward...

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Veröffentlicht in:	Chemical science (Cambridge) 2023-03, Vol.14 (1), p.2755-2762
Hauptverfasser:	Nilova, Aleksandra, Mannchen, Michael D, Noel, Abdias N, Semenova, Evgeniya, Grenning, Alexander J
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