Hyperpolarization study on remdesivir with its biological reaction monitoring signal amplification by reversible exchange

Hyperpolarization study on remdesivir with its biological reaction monitoring signal amplification by reversible exchange

Our experiments indicate hyperpolarized proton signals in the entire structure of remdesivir are obtained due to a long-distance polarization transfer by para -hydrogen. SABRE-based biological real-time reaction monitoring, by using a protein enzyme under mild conditions is carried out. It represent...

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Veröffentlicht in:RSC advances 2022-02, Vol.12 (7), p.4377-4381
Hauptverfasser: Jeong, Hye Jin, Min, Sein, Kim, Sarah, Namgoong, Sung Keon, Jeong, Keunhong
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container_issue 7
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container_title RSC advances
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creator Jeong, Hye Jin
Min, Sein
Kim, Sarah
Namgoong, Sung Keon
Jeong, Keunhong
description Our experiments indicate hyperpolarized proton signals in the entire structure of remdesivir are obtained due to a long-distance polarization transfer by para -hydrogen. SABRE-based biological real-time reaction monitoring, by using a protein enzyme under mild conditions is carried out. It represents the first successful para -hydrogen based hyperpolarization application in biological reaction monitoring. Hyperpolarized proton signals in the entire structure of remdesivir are obtained due to a long-distance polarization transfer by para -hydrogen. Biological real-time reaction monitoring, by using a protein enzyme under mild conditions is carried out.
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title Hyperpolarization study on remdesivir with its biological reaction monitoring signal amplification by reversible exchange
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