TBHP-mediated photochemical coupling/cyclization of -arylacrylamides with thiols
The effective photoredox-mediated oxidative thiolation and cyclization of N -arylacrylamides with thiols leads to biologically interesting 3-thionated oxindoles through C-S and C-C bond formation. This process represents a straightforward reaction that starts from non-prefunctionalized thiolating re...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2023-02, Vol.21 (5), p.94-944 |
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| container_end_page | 944 |
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| container_issue | 5 |
| container_start_page | 94 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 21 |
| creator | Qu, Zhonghua Ji, Xiaochen Tian, Lin Mao, Guojiang Deng, Guo-Jun Huang, Huawen |
| description | The effective photoredox-mediated oxidative thiolation and cyclization of
N
-arylacrylamides with thiols leads to biologically interesting 3-thionated oxindoles through C-S and C-C bond formation. This process represents a straightforward reaction that starts from non-prefunctionalized thiolating reagents. Mechanistic studies demonstrated that the TBHP serves as a key radical initiator with visible-light catalysis.
TBHP-mediated thiyl couplings: A mild and metal-free visible-light-induced system allows sequential thiolation/cyclization of
N
-aryl acrylamides and mercaptans and provides an access to thionated oxindoles with potential biological activity. |
| doi_str_mv | 10.1039/d2ob02187k |
| format | Article |
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N
-arylacrylamides with thiols leads to biologically interesting 3-thionated oxindoles through C-S and C-C bond formation. This process represents a straightforward reaction that starts from non-prefunctionalized thiolating reagents. Mechanistic studies demonstrated that the TBHP serves as a key radical initiator with visible-light catalysis.
TBHP-mediated thiyl couplings: A mild and metal-free visible-light-induced system allows sequential thiolation/cyclization of
N
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-arylacrylamides with thiols leads to biologically interesting 3-thionated oxindoles through C-S and C-C bond formation. This process represents a straightforward reaction that starts from non-prefunctionalized thiolating reagents. Mechanistic studies demonstrated that the TBHP serves as a key radical initiator with visible-light catalysis.
TBHP-mediated thiyl couplings: A mild and metal-free visible-light-induced system allows sequential thiolation/cyclization of
N
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-arylacrylamides with thiols leads to biologically interesting 3-thionated oxindoles through C-S and C-C bond formation. This process represents a straightforward reaction that starts from non-prefunctionalized thiolating reagents. Mechanistic studies demonstrated that the TBHP serves as a key radical initiator with visible-light catalysis.
TBHP-mediated thiyl couplings: A mild and metal-free visible-light-induced system allows sequential thiolation/cyclization of
N
-aryl acrylamides and mercaptans and provides an access to thionated oxindoles with potential biological activity.</abstract><doi>10.1039/d2ob02187k</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Organic & biomolecular chemistry, 2023-02, Vol.21 (5), p.94-944 |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | TBHP-mediated photochemical coupling/cyclization of -arylacrylamides with thiols |
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