Organocatalytic cascade nucleophilic/aza-Michael addition reactions: metal-free catalytic strategy for the synthesis of hydantoins

Lewis base-catalyzed cascade nucleophilic/aza-Michael addition reaction of N -alkoxy β-oxo-acrylamides with isocyanates has been developed to afford various highly functionalized hydantoin derivatives in 80-98% yields under mild reaction conditions. The intriguing features of this method include met...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic & biomolecular chemistry 2023-03, Vol.21 (11), p.2295-23
Hauptverfasser:	Xie, Lei, Sun, Lei, Wu, Ping, Wang, Zhaoxue, Zhao, Chenyi, Wu, Lingang, Li, Xiaojing, Gao, Zhenzhen, Liu, Wanxing, Nie, Shao-zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Cascade chemical reactions Catalysts Chemical synthesis Hydantoin Isocyanates Lewis base Michael reaction Substrates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!