Rh()-catalyzed synthesis of 5-isochromeno[3,4-]indolizines from 4-diazoisochroman-3-imines and pyridines

A Rh( ii )-catalyzed (3 + 2) annulation of pyridines with 4-diazoisochroman-3-imines leading to 5 H -isochromeno[3,4- b ]indolizines is presented. This methodology provides straightforward access to a wide variety of substituted 5 H -isochromeno[3,4- b ]indolizines with moderate to good yields (up t...

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Veröffentlicht in:Organic & biomolecular chemistry 2022-11, Vol.2 (43), p.8484-8488
Hauptverfasser: Wang, Yingxiao, Xie, Jianwei, Lu, Ping, Wang, Yanguang
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creator Wang, Yingxiao
Xie, Jianwei
Lu, Ping
Wang, Yanguang
description A Rh( ii )-catalyzed (3 + 2) annulation of pyridines with 4-diazoisochroman-3-imines leading to 5 H -isochromeno[3,4- b ]indolizines is presented. This methodology provides straightforward access to a wide variety of substituted 5 H -isochromeno[3,4- b ]indolizines with moderate to good yields (up to 84%) and complete regioselectivity. A Rh( ii )-catalyzed (3 + 2) annulation of pyridines with 4-diazoisochroman-3-imines furnished 5 H -isochromeno[3,4- b ]indolizines with moderate to good yields and complete regioselectivity.
doi_str_mv 10.1039/d2ob01400a
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title Rh()-catalyzed synthesis of 5-isochromeno[3,4-]indolizines from 4-diazoisochroman-3-imines and pyridines
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