Synthesis of spirocyclic oxazole derivatives from 2-arylidene cycloalkanones and -halohydroxamates
Herein we disclose a facile route to spirocyclic oxazole derivatives via [3 + 2] cycloaddition reactions between 2-arylidene cycloalkanones and azaoxyallyl cations that formed in situ from α-halohydroxamates in the presence of base. This methodology was shown to lead to an efficient formation of a s...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2022-06, Vol.2 (21), p.4293-4297 |
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| container_issue | 21 |
| container_start_page | 4293 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 2 |
| creator | Wan, Huiyang Xia, Shuangshuang Liu, Xinghua Jian, Yongchan An, Yuanyuan Wang, Yubin |
| description | Herein we disclose a facile route to spirocyclic oxazole derivatives
via
[3 + 2] cycloaddition reactions between 2-arylidene cycloalkanones and azaoxyallyl cations that formed
in situ
from α-halohydroxamates in the presence of base. This methodology was shown to lead to an efficient formation of a series of functionalized spirocyclic oxazole derivatives in good to excellent yields.
A facil route to spirocyclic oxazole derivatives
via
the [3 + 2] cycloaddition reactions between 2-arylidene cycloalkanones and azaoxyallyl cations was developed. |
| doi_str_mv | 10.1039/d2ob00701k |
| format | Article |
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via
[3 + 2] cycloaddition reactions between 2-arylidene cycloalkanones and azaoxyallyl cations that formed
in situ
from α-halohydroxamates in the presence of base. This methodology was shown to lead to an efficient formation of a series of functionalized spirocyclic oxazole derivatives in good to excellent yields.
A facil route to spirocyclic oxazole derivatives
via
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via
[3 + 2] cycloaddition reactions between 2-arylidene cycloalkanones and azaoxyallyl cations that formed
in situ
from α-halohydroxamates in the presence of base. This methodology was shown to lead to an efficient formation of a series of functionalized spirocyclic oxazole derivatives in good to excellent yields.
A facil route to spirocyclic oxazole derivatives
via
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via
[3 + 2] cycloaddition reactions between 2-arylidene cycloalkanones and azaoxyallyl cations that formed
in situ
from α-halohydroxamates in the presence of base. This methodology was shown to lead to an efficient formation of a series of functionalized spirocyclic oxazole derivatives in good to excellent yields.
A facil route to spirocyclic oxazole derivatives
via
the [3 + 2] cycloaddition reactions between 2-arylidene cycloalkanones and azaoxyallyl cations was developed.</abstract><doi>10.1039/d2ob00701k</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2022-06, Vol.2 (21), p.4293-4297 |
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| recordid | cdi_rsc_primary_d2ob00701k |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Synthesis of spirocyclic oxazole derivatives from 2-arylidene cycloalkanones and -halohydroxamates |
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