PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery

We describe a novel approach for screening fragments against a protein that combines the sensitivity of DNA-encoded library technology with the ability of fragments to explore what will bind. Each of the members of the library consists of a fragment which is linked to a photoactivatable diazirine mo...

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Veröffentlicht in:	MedChemComm 2022-11, Vol.13 (11), p.1341-1349
Hauptverfasser:	Ma, Huiyong, Murray, James B, Luo, Huadong, Cheng, Xuemin, Chen, Qiuxia, Song, Chao, Duan, Cong, Tan, Ping, Zhang, Lifang, Liu, Jian, Morgan, Barry A, Li, Jin, Wan, Jinqiao, Baker, Lisa M, Finnie, William, Guetzoyan, Lucie, Harris, Richard, Hendrickson, Nicole, Matassova, Natalia, Simmonite, Heather, Smith, Julia, Hubbard, Roderick E, Liu, Guansai
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Crystal structure Deoxyribonucleic acid DNA DNA structure Epimerase Fragments Genetic testing Kinases Libraries NMR Nuclear magnetic resonance Photoactivation Proteins Screening
Online-Zugang:	Volltext
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