Selectivity mechanism of muscarinic acetylcholine receptor antagonism through investigation

Structures of muscarinic acetylcholine receptors illustrate the strikingly high degree of homology of the residues among isoforms, thus leading to difficulty in achieving subtype selectivity when targeting these receptors and causing undesired side effects when treating the corresponding diseases. C...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2022-11, Vol.24 (42), p.26269-26287
Hauptverfasser:	Chen, Lu, Hu, Baichun, Wang, Hanxun, Li, Weixia, Wang, Shizun, Luan, Jiasi, Liu, Haihan, Wang, Jian, Cheng, Maosheng
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