Novel salts and cocrystals of the antifolate drug trimethoprim and their role in the enhancement of solubility and dissolution

Trimethoprim (TMP) is a BCS class II anti-folate drug with poor aqueous solubility. Four new crystal structures of TMP were developed in this work using a supramolecular synthon approach with coformers theophylline-7-acetic acid (T7A), 5-fluorouracil (5FU), catechol (CAT) and thymine (THY). The carb...

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Veröffentlicht in:	CrystEngComm 2023-02, Vol.25 (8), p.122-1231
Hauptverfasser:	Surampudi, Anuja Venkata Sai Durga, Ramakrishna, Sistla, Pallavi, Alegete, Balasubramanian, Sridhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Catechol Dissolution Hydroxyl groups Melt temperature Melting Solubility Theophylline Thymine Trimethoprim
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