Highly inert Cu() complexes of -aryl bifunctional cyclam-picolinates with remarkable Cu-labelling and biodistribution
Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64 Cu-radiocomplexes. The C -aryl functionalization strategy developed here preserves t...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2023-01, Vol.59 (7), p.888-891 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Pineau, Julie Lima, Luís M. P Le Roy, Marie M Marionneau-Lambot, Séverine Cordier, Marie Le Saëc, Patricia Zeevaart, Jan Rijn Driver, Cathryn H. S Faivre-Chauvet, Alain Le Bris, Nathalie Tripier, Raphaël |
| description | Cyclam-picolinate chelators were functionalized
via
click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding
64
Cu-radiocomplexes. The
C
-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
Two bifunctional copper chelators H
2
TE1PA-trz-prA
and H
2
CB-TE1PA-trz-prA
were synthesized and their relevant
nat
Cu- and
64
Cu-complex properties highlighted. |
| doi_str_mv | 10.1039/d2cc06602e |
| format | Article |
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via
click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding
64
Cu-radiocomplexes. The
C
-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
Two bifunctional copper chelators H
2
TE1PA-trz-prA
and H
2
CB-TE1PA-trz-prA
were synthesized and their relevant
nat
Cu- and
64
Cu-complex properties highlighted.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d2cc06602e</identifier><ispartof>Chemical communications (Cambridge, England), 2023-01, Vol.59 (7), p.888-891</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Pineau, Julie</creatorcontrib><creatorcontrib>Lima, Luís M. P</creatorcontrib><creatorcontrib>Le Roy, Marie M</creatorcontrib><creatorcontrib>Marionneau-Lambot, Séverine</creatorcontrib><creatorcontrib>Cordier, Marie</creatorcontrib><creatorcontrib>Le Saëc, Patricia</creatorcontrib><creatorcontrib>Zeevaart, Jan Rijn</creatorcontrib><creatorcontrib>Driver, Cathryn H. S</creatorcontrib><creatorcontrib>Faivre-Chauvet, Alain</creatorcontrib><creatorcontrib>Le Bris, Nathalie</creatorcontrib><creatorcontrib>Tripier, Raphaël</creatorcontrib><title>Highly inert Cu() complexes of -aryl bifunctional cyclam-picolinates with remarkable Cu-labelling and biodistribution</title><title>Chemical communications (Cambridge, England)</title><description>Cyclam-picolinate chelators were functionalized
via
click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding
64
Cu-radiocomplexes. The
C
-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
Two bifunctional copper chelators H
2
TE1PA-trz-prA
and H
2
CB-TE1PA-trz-prA
were synthesized and their relevant
nat
Cu- and
64
Cu-complex properties highlighted.</description><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFj09rAjEUxEOpUFu99F54Rz2kZt0_1bMofoAeepO32ay-9m2yJFna_faNUOjRuczADD8YIZ4z9ZqpfLtq1lqrqlJrcyemWV4Vsiw2H_fXXG7lW16UD-IxhE-VlJWbqRiOdL7wCGSNj7AbFkvQruvZ_JgArgWJfmSoqR2sjuQsMuhRM3ayJ-2YLMY0_KZ4AW869F9Ys0kcyVgbTv0Z0DYJ4BoK0VM9XCkzMWmRg5n_-ZN4Oezfd0fpgz71nhJoPP1_yW_1v1gbTu8</recordid><startdate>20230119</startdate><enddate>20230119</enddate><creator>Pineau, Julie</creator><creator>Lima, Luís M. P</creator><creator>Le Roy, Marie M</creator><creator>Marionneau-Lambot, Séverine</creator><creator>Cordier, Marie</creator><creator>Le Saëc, Patricia</creator><creator>Zeevaart, Jan Rijn</creator><creator>Driver, Cathryn H. S</creator><creator>Faivre-Chauvet, Alain</creator><creator>Le Bris, Nathalie</creator><creator>Tripier, Raphaël</creator><scope/></search><sort><creationdate>20230119</creationdate><title>Highly inert Cu() complexes of -aryl bifunctional cyclam-picolinates with remarkable Cu-labelling and biodistribution</title><author>Pineau, Julie ; Lima, Luís M. P ; Le Roy, Marie M ; Marionneau-Lambot, Séverine ; Cordier, Marie ; Le Saëc, Patricia ; Zeevaart, Jan Rijn ; Driver, Cathryn H. S ; Faivre-Chauvet, Alain ; Le Bris, Nathalie ; Tripier, Raphaël</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_d2cc06602e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pineau, Julie</creatorcontrib><creatorcontrib>Lima, Luís M. P</creatorcontrib><creatorcontrib>Le Roy, Marie M</creatorcontrib><creatorcontrib>Marionneau-Lambot, Séverine</creatorcontrib><creatorcontrib>Cordier, Marie</creatorcontrib><creatorcontrib>Le Saëc, Patricia</creatorcontrib><creatorcontrib>Zeevaart, Jan Rijn</creatorcontrib><creatorcontrib>Driver, Cathryn H. S</creatorcontrib><creatorcontrib>Faivre-Chauvet, Alain</creatorcontrib><creatorcontrib>Le Bris, Nathalie</creatorcontrib><creatorcontrib>Tripier, Raphaël</creatorcontrib><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pineau, Julie</au><au>Lima, Luís M. P</au><au>Le Roy, Marie M</au><au>Marionneau-Lambot, Séverine</au><au>Cordier, Marie</au><au>Le Saëc, Patricia</au><au>Zeevaart, Jan Rijn</au><au>Driver, Cathryn H. S</au><au>Faivre-Chauvet, Alain</au><au>Le Bris, Nathalie</au><au>Tripier, Raphaël</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly inert Cu() complexes of -aryl bifunctional cyclam-picolinates with remarkable Cu-labelling and biodistribution</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><date>2023-01-19</date><risdate>2023</risdate><volume>59</volume><issue>7</issue><spage>888</spage><epage>891</epage><pages>888-891</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Cyclam-picolinate chelators were functionalized
via
click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding
64
Cu-radiocomplexes. The
C
-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
Two bifunctional copper chelators H
2
TE1PA-trz-prA
and H
2
CB-TE1PA-trz-prA
were synthesized and their relevant
nat
Cu- and
64
Cu-complex properties highlighted.</abstract><doi>10.1039/d2cc06602e</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2023-01, Vol.59 (7), p.888-891 |
| issn | 1359-7345 1364-548X |
| language | |
| recordid | cdi_rsc_primary_d2cc06602e |
| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| title | Highly inert Cu() complexes of -aryl bifunctional cyclam-picolinates with remarkable Cu-labelling and biodistribution |
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