Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem

The first systematic study of ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution (DYRKR) on aryl α-chloro β-keto esters was performed, and 15 structurally diverse chiral anti -aryl α-chloro β-hydroxy esters were synthesized in 74-98% isolated yields, along with moderate-to-excellent...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2022-08, Vol.58 (64), p.91-913
Hauptverfasser:	Yue, Xiaoping, Li, Yitong, Liu, Minjie, Sang, Di, Huang, Zedu, Chen, Fener
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic compounds Chemical reduction Diltiazem Enantiomers Esters Stereoselectivity Substrates Synthesis
Online-Zugang:	Volltext
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