Synthesis of 1,2-oxazetidines with a free -NH group photoredox catalysis

A photoredox approach enabling one-step synthesis of oxazetidines with a free -NH group via the combined use of alkyne, thiophenol, and azide has been reported. The synthesized oxazetidine with the free -NH group was stable enough for various late-stage transformations such as methylation, acetylati...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-07, Vol.58 (61), p.858-8511
Hauptverfasser: Ganie, Majid Ahmad, Bhat, Muneer-Ul-Shafi, Rizvi, Masood Ahmad, Raheem, Shabnam, Shah, Bhahwal Ali
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container_end_page 8511
container_issue 61
container_start_page 858
container_title Chemical communications (Cambridge, England)
container_volume 58
creator Ganie, Majid Ahmad
Bhat, Muneer-Ul-Shafi
Rizvi, Masood Ahmad
Raheem, Shabnam
Shah, Bhahwal Ali
description A photoredox approach enabling one-step synthesis of oxazetidines with a free -NH group via the combined use of alkyne, thiophenol, and azide has been reported. The synthesized oxazetidine with the free -NH group was stable enough for various late-stage transformations such as methylation, acetylation, tosylation, and ring-opening reaction to afford synthetically useful α-aminoketones. A photoredox approach enabling one-step synthesis of oxazetidines with a free -NH group via the combined use of alkyne, thiophenol, and azide has been reported.
doi_str_mv 10.1039/d2cc02892a
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title Synthesis of 1,2-oxazetidines with a free -NH group photoredox catalysis
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