Metformin reprograms tumor microenvironment and boosts chemoimmunotherapy in colorectal cancer

Tumor stroma plays an important role in the occurrence, development, and metastasis of colorectal cancer (CRC). The dense collagenous stroma forms a physical barrier for antitumor drugs and sustains a highly tumor immunosuppressive microenvironment. To address this issue, a spatiotemporal combinatio...

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Veröffentlicht in:	Biomaterials science 2022-09, Vol.1 (19), p.5596-567
Hauptverfasser:	Ni, Weidong, Wu, Jiayan, Feng, Yuanji, Hu, Yingying, Liu, Haiyan, Chen, Jie, Chen, Fangfang, Tian, Huayu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Barriers Cancer Cell death Colorectal cancer Functional materials Hyaluronic acid Immune system Metformin Nanoparticles
Online-Zugang:	Volltext
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