CFSOH-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles
A novel dearomatization process to produce fused polycyclic indolines via a CF 3 SO 3 H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excelle...
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Veröffentlicht in: | Organic & biomolecular chemistry 2021-05, Vol.19 (2), p.4469-4473 |
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container_title | Organic & biomolecular chemistry |
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creator | Yao, Zhengdong Feng, Huangdi Xi, Hui Xi, Chuanjun Liu, Weiping |
description | A novel dearomatization process to produce fused polycyclic indolines
via
a CF
3
SO
3
H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excellent yields, as well as with good functional group tolerance. Moreover, transformation of the product was performed to deliver the corresponding acid, alcohol and amide smoothly.
A novel dearomatization process to produce fused polycyclic indolines
via
a CF
3
SO
3
H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. |
doi_str_mv | 10.1039/d1ob00712b |
format | Article |
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via
a CF
3
SO
3
H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excellent yields, as well as with good functional group tolerance. Moreover, transformation of the product was performed to deliver the corresponding acid, alcohol and amide smoothly.
A novel dearomatization process to produce fused polycyclic indolines
via
a CF
3
SO
3
H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/d1ob00712b</identifier><ispartof>Organic & biomolecular chemistry, 2021-05, Vol.19 (2), p.4469-4473</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Yao, Zhengdong</creatorcontrib><creatorcontrib>Feng, Huangdi</creatorcontrib><creatorcontrib>Xi, Hui</creatorcontrib><creatorcontrib>Xi, Chuanjun</creatorcontrib><creatorcontrib>Liu, Weiping</creatorcontrib><title>CFSOH-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles</title><title>Organic & biomolecular chemistry</title><description>A novel dearomatization process to produce fused polycyclic indolines
via
a CF
3
SO
3
H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excellent yields, as well as with good functional group tolerance. Moreover, transformation of the product was performed to deliver the corresponding acid, alcohol and amide smoothly.
A novel dearomatization process to produce fused polycyclic indolines
via
a CF
3
SO
3
H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated.</description><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFjjsLwjAUhYMoWB-Lu5A_EJu0auksFjcH3Uua3Gok5pakCPXXW0F0dDh857EcQhaCrwRP81gLrDjPRFINSCTWWcb4Js2HX5_wMZmEcONc5Nl2HRG1K07HAwMnKwuaKhmU1EC9cReGDbiesQbp8S5b8-yFjmJNjdNogWrw5tGXDwi0Rdqg7VSnrFH0Ci14fAcIMzKqpQ0w_3BKlsX-vDswH1TZeHOXvit_z9N_-wu0t0iS</recordid><startdate>20210526</startdate><enddate>20210526</enddate><creator>Yao, Zhengdong</creator><creator>Feng, Huangdi</creator><creator>Xi, Hui</creator><creator>Xi, Chuanjun</creator><creator>Liu, Weiping</creator><scope/></search><sort><creationdate>20210526</creationdate><title>CFSOH-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles</title><author>Yao, Zhengdong ; Feng, Huangdi ; Xi, Hui ; Xi, Chuanjun ; Liu, Weiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_d1ob00712b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Zhengdong</creatorcontrib><creatorcontrib>Feng, Huangdi</creatorcontrib><creatorcontrib>Xi, Hui</creatorcontrib><creatorcontrib>Xi, Chuanjun</creatorcontrib><creatorcontrib>Liu, Weiping</creatorcontrib><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Zhengdong</au><au>Feng, Huangdi</au><au>Xi, Hui</au><au>Xi, Chuanjun</au><au>Liu, Weiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CFSOH-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles</atitle><jtitle>Organic & biomolecular chemistry</jtitle><date>2021-05-26</date><risdate>2021</risdate><volume>19</volume><issue>2</issue><spage>4469</spage><epage>4473</epage><pages>4469-4473</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>A novel dearomatization process to produce fused polycyclic indolines
via
a CF
3
SO
3
H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excellent yields, as well as with good functional group tolerance. Moreover, transformation of the product was performed to deliver the corresponding acid, alcohol and amide smoothly.
A novel dearomatization process to produce fused polycyclic indolines
via
a CF
3
SO
3
H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated.</abstract><doi>10.1039/d1ob00712b</doi><tpages>5</tpages></addata></record> |
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source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
title | CFSOH-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles |
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