CFSOH-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles

A novel dearomatization process to produce fused polycyclic indolines via a CF 3 SO 3 H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excelle...

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Veröffentlicht in:Organic & biomolecular chemistry 2021-05, Vol.19 (2), p.4469-4473
Hauptverfasser: Yao, Zhengdong, Feng, Huangdi, Xi, Hui, Xi, Chuanjun, Liu, Weiping
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creator Yao, Zhengdong
Feng, Huangdi
Xi, Hui
Xi, Chuanjun
Liu, Weiping
description A novel dearomatization process to produce fused polycyclic indolines via a CF 3 SO 3 H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excellent yields, as well as with good functional group tolerance. Moreover, transformation of the product was performed to deliver the corresponding acid, alcohol and amide smoothly. A novel dearomatization process to produce fused polycyclic indolines via a CF 3 SO 3 H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated.
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title CFSOH-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles
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