Ruthenium-catalyzed -alkylation of amino-1,3,5-triazines using alcohols

An efficient ruthenium-catalyzed N -alkylation of amino 1,3,5-triazines with alcohols was achieved via a BH/HA strategy. Following this simple, facile, and high atom economical protocol, a broad range of products was prepared in moderate to good yields and heterocyclic or benzylic alcohols containin...

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Veröffentlicht in:New journal of chemistry 2021-09, Vol.45 (35), p.15776-15779
Hauptverfasser: Zhao, Junna, Zhong, Pengzhen, Xie, Zhongpao, Zhou, Wei, Zhang, Chen, Cui, Dong-Mei
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container_end_page 15779
container_issue 35
container_start_page 15776
container_title New journal of chemistry
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creator Zhao, Junna
Zhong, Pengzhen
Xie, Zhongpao
Zhou, Wei
Zhang, Chen
Cui, Dong-Mei
description An efficient ruthenium-catalyzed N -alkylation of amino 1,3,5-triazines with alcohols was achieved via a BH/HA strategy. Following this simple, facile, and high atom economical protocol, a broad range of products was prepared in moderate to good yields and heterocyclic or benzylic alcohols containing various functionalities were tolerated. The application of the reaction is also further demonstrated by the synthesis of alkylated secondary amine-1,3,5-triazines from olefinated amino-1,3,5-triazines and alcohols via a one pot N -alkylation and reductive reactions. An efficient ruthenium-catalyzed N -alkylation of amino-1,3,5-triazines with alcohols was achieved via BH/HA strategy.
doi_str_mv 10.1039/d1nj03116c
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title Ruthenium-catalyzed -alkylation of amino-1,3,5-triazines using alcohols
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